Stereoselective synthesis of α-fluoroacrylonitriles via organocatalytic cyanation of gem-difluoroalkenes and TMSCN†,New Journal of Chemistry

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Stereoselective synthesis of α-fluoroacrylonitriles via organocatalytic cyanation of gem-difluoroalkenes and TMSCN†
New Journal of Chemistry ( IF 3.3 ) Pub Date : 2019-06-19 00:00:00 , DOI: 10.1039/c9nj02370d
Yu-Chuan Ma _{1,

2,

3,

4} , Yang Zhang _{1,

2,

3,

4} , Cheng-Zhi Gu _{1,

2,

3,

4} , Guang-Fen Du _{1,

2,

3,

4} , Lin He _{1,

2,

3,

4}

Affiliation

An organocatalytic cyanation reaction of gem-difluoroalkenes was developed. Under the catalysis of 10 mol% DBU, gem-difluoroalkenes undergo a nucleophilic addition-β-elimination reaction with trimethylsilyl cyanide to provide α-fluoroacrylonitriles in 50–98% yields with excellent Z/E selectivity.

中文翻译：

α-fluoroacrylonitriles的立体选择性合成通过的有机催化氰化宝石-difluoroalkenes和TMSCN †

开发了宝石-二氟烯烃的有机催化氰化反应。在10摩尔％DBU的催化下，宝石-二氟烯烃与三甲基甲硅烷基氰化物进行亲核加成-β-消除反应，以50-98％的产率提供具有优异Z / E选择性的α-氟代丙烯腈。

更新日期：2019-06-19

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