Complex adult behaviors arise from the integration of sequential and often overlapping critical periods (CPs) early in life and adolescence. These processes rely on a subtle interplay between the set of genes inherited from the parents, the surrounding environment and epigenetic regulation. Methyl-CpG-binding protein 2 (MeCP2) has been shown to recognize epigenetic states and regulate gene expression by reading methylated DNA. Here, we will review the recent findings revealing the role of MeCP2 during postnatal CPs of development using mouse models of Rett (RTT) syndrome.

中文翻译：

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MeCP2：关键时期的表观遗传调控因子。

复杂的成人行为是由于生命和青春期早期的连续且经常重叠的关键时期（CP）的整合而产生的。这些过程依赖于从亲本遗传的基因组，周围环境和表观遗传调控之间的微妙相互作用。已显示甲基CpG结合蛋白2（MeCP2）可以识别表观遗传状态并通过读取甲基化DNA来调节基因表达。在这里，我们将使用Rett（RTT）综合征小鼠模型回顾最近的发现，揭示MeCP2在产后CP发育过程中的作用。