Cardiovascular diseases (CVDs) are the main cause of morbidity and mortality in Western society and present an important age-related risk. With the constant rise in life expectancy, prevalence of CVD in the population will likely increase further. New therapies, especially in the elderly, are needed to combat CVD. This review is focused on the role of long noncoding RNA (lncRNA) in CVD. RNA sequencing experiments in the past decade showed that most RNA does not code for protein, but many RNAs function as ncRNA. Here, we summarize the recent findings of lncRNA regulation in the diseased heart. The potential use of these RNAs as biomarkers of cardiac disease prediction is also discussed.

中文翻译：

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长的非编码RNA在心脏衰老和疾病中。

心血管疾病（CVD）是西方社会发病和死亡的主要原因，并且是与年龄相关的重要风险。随着预期寿命的不断提高，CVD在人群中的患病率可能会进一步上升。需要新的疗法，特别是在老年人中，以对抗CVD。这篇综述的重点是长非编码RNA（lncRNA）在CVD中的作用。过去十年中的RNA测序实验表明，大多数RNA都不编码蛋白质，但是许多RNA都具有ncRNA的功能。在这里，我们总结了患病心脏中lncRNA调控的最新发现。还讨论了这些RNA作为心脏病预测生物标志物的潜在用途。