Plexin D1 belongs to a family of transmembrane proteins called plexins. It was characterized as a receptor for semaphorins and is known to be essential for axonal guidance and vascular patterning. Mutations in Plexin D1 have been implicated in pathologic conditions such as truncus arteriosus and Möbius syndrome. Emerging data show that expression of Plexin D1 is deregulated in several cancers; it can support tumor development by aiding in tumor metastasis and EMT; and conversely, it can act as a dependence receptor and stimulate cell death in the absence of its canonical ligand, semaphorin 3E. The role of Plexin D1 in tumor development and progression is thereby garnering research interest for its potential as a biomarker and as a therapeutic target. In this review, we describe its discovery, structure, mutations, role(s) in cancer, and therapeutic potential.

丛蛋白D1属于一种称为plexins的跨膜蛋白家族。它被表征为信号量的受体，并且已知对于轴突引导和血管形成是必不可少的。Plexin D1中的突变与病理状况有关，例如动脉干和莫比乌斯综合症。新兴数据表明，在几种癌症中，Plexin D1的表达均被下调。通过辅助肿瘤转移和EMT，可以支持肿瘤的发展。相反，它可以在不存在其经典配体semaphorin 3E的情况下充当依赖性受体并刺激细胞死亡。Plexin D1在肿瘤发生和发展中的作用因其作为生物标志物和治疗靶标的潜力而赢得了研究兴趣。在这篇综述中，我们描述了其在癌症中的发现，结构，突变，作用，