Chronic liver disease results in fibrosis and cancer. While injury is associated with mutational burden, a recent study (Zhu et al. Cell 2019;177:608–621) highlights that not all positively selected mutations in the liver are precancerous. Indeed, some may be beneficial to the ability of the liver to not only withstand injury , but also to regenerate.

中文翻译：

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肝病中的有益非癌性突变

慢性肝病会导致纤维化和癌症。虽然损伤与突变负担相关，但最近的一项研究 (Zhu et al. Cell 2019;177:608-621) 强调，并非所有肝脏中阳性选择的突变都是癌前病变。事实上，有些可能有益于肝脏的能力，不仅可以承受伤害，还可以再生。