In this review, we summarize data regarding the influence of zinc on host defenses to human pathogenic fungi and how the fungus acquires zinc to sustain biological functions. Mammals have evolved several extracellular and intracellular mechanisms to withhold zinc from the fungus. Specific immune cells release zinc binding proteins such as calprotectin to capture the metal and deny it to the fungus. Intracellularly, several zinc binding proteins such as metallothioneins starve the fungus of zinc. The net result in both situations is depriving the fungus of a crucial micronutrient. To combat this struggle, fungi have developed means to capture zinc and store it. The mechanisms of transport for various fungi are discussed herein.

中文翻译：

---

宿主和真菌通过锌透镜的交叉点。

在这篇综述中，我们总结了有关锌对宿主防御人类病原性真菌的影响以及真菌如何获取锌以维持生物学功能的数据。哺乳动物已经进化出几种细胞外和细胞内机制来从真菌中扣留锌。特定的免疫细胞释放锌结合蛋白（例如钙卫蛋白）以捕获金属并将其否认为真菌。在细胞内，几种锌结合蛋白（例如金属硫蛋白）使锌的真菌饥饿。两种情况下的最终结果都是使真菌失去了至关重要的微量营养素。为了与这种斗争作斗争，真菌已经开发出捕获锌并将其储存的方法。本文讨论了各种真菌的运输机制。