Reproduction, i.e. the ability to produce new individuals from a parent organism, is a hallmark of living matter. Even the simplest forms of reproduction require cell division: attempts to create a designer cell therefore should include a synthetic cell division machinery. In this review, we will illustrate how nature solves this task, describing membrane remodelling processes in general and focusing on bacterial cell division in particular. We discuss recent progress made in their in vitro reconstitution, identify open challenges, and suggest how purely synthetic building blocks could provide an additional and attractive route to creating artificial cell division machineries.

中文翻译：

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通过膜转化分子组装体进行合成细胞分裂

繁殖，即从亲代生物中产生新个体的能力，是生物的标志。即使是最简单的复制形式也需要细胞分裂：因此，创建设计者细胞的尝试应包括合成细胞分裂机制。在这篇综述中，我们将说明自然界如何解决这一任务，总体上描述膜重塑过程，并特别关注细菌细胞分裂。我们讨论了他们在体外重建中取得的最新进展，确定了开放性挑战，并提出了纯合成构件如何为创建人造细胞分裂机制提供额外且有吸引力的途径的建议。