Contemporary mouse genetic reference populations are a powerful platform to discover complex disease mechanisms. Advanced high-diversity mouse populations include the Collaborative Cross (CC) strains, Diversity Outbred (DO) stock, and their isogenic founder strains. When used in systems genetics and integrative genomics analyses, these populations efficiently harnesses known genetic variation for precise and contextualized identification of complex disease mechanisms. Extensive genetic, genomic, and phenotypic data are already available for these high-diversity mouse populations and a growing suite of data analysis tools have been developed to support research on diverse mice. This integrated resource can be used to discover and evaluate disease mechanisms relevant across species.

中文翻译：

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高多样性小鼠种群的复杂性状。

当代小鼠遗传参考种群是发现复杂疾病机制的强大平台。先进的高多样性小鼠种群包括协作十字（CC）品系，多样性近交（DO）种群及其同基因的建立者品系。当在系统遗传学和综合基因组学分析中使用时，这些种群有效地利用已知的遗传变异对复杂疾病机制进行精确和情境鉴定。这些高多样性小鼠群体已经获得了广泛的遗传，基因组和表型数据，并且已经开发了一套不断增长的数据分析工具来支持对各种小鼠的研究。该综合资源可用于发现和评估跨物种相关的疾病机制。