The MEF2 family of transcription factors regulate large programs of gene expression important for the development and maintenance of many tissues, including the brain. MEF2 proteins are regulated by neuronal synaptic activity, and they recruit several epigenetic enzymes to influence chromatin structure and gene expression during development and throughout adulthood. Here, we provide a brief review of the recent literature reporting important roles for MEF2 during early brain development and function, and we highlight emerging roles for MEF2 as a risk factor for multiple neurodevelopmental disorders and mental illnesses, such as autism, intellectual disability, and schizophrenia.

中文翻译：

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MEF2在大脑发育和精神障碍中的新兴作用。

MEF2转录因子家族可调节大型基因表达程序，对许多组织（包括大脑）的发育和维持都很重要。MEF2蛋白受神经元突触活动的调节，它们募集了几种表观遗传酶来影响染色质的结构和在发育过程中以及整个成年期的基因表达。在这里，我们简要回顾了最近的文献，这些文献报道了MEF2在早期大脑发育和功能中的重要作用，并且我们着重指出了MEF2作为多种神经发育障碍和精神疾病（例如自闭症，智力障碍和精神病）的危险因素的新兴作用。精神分裂症。