Metabolic reprogramming as well as the flexible utilisation of fuel sources by tumour cells has been considered not only intrinsic to malignant cells but also sustained by resident and/or recruited stromal cells. The complexity of tumour-stroma cross-talk is experienced by neoplastic cells through profound changes in the own metabolic machinery. In such context, mitochondria are dynamic organelles that receive, orchestrate and exchange a multiplicity of stromal cues within the tumour cells to finely regulate key metabolic and signalling pathways, allowing malignant cells to adapt and thrive in an ever-changing environment. In this review, we focus on how tumour mitochondria are coached by stromal metabolic supply and how this re-education sustains tumour malignant traits.

中文翻译：

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基质诱导的线粒体再教育：对上皮-间充质转化和癌症侵袭性的影响。

不仅考虑到恶性细胞固有的代谢重编程以及肿瘤细胞对燃料来源的灵活利用，而且还考虑到常驻和/或募集的基质细胞可以维持这种代谢。肿瘤细胞通过自身代谢机制的深刻变化经历了肿瘤-基质相声的复杂性。在这种情况下，线粒体是动态细胞器，它们在肿瘤细胞内接收，编排和交换多种基质线索，以精细调节关键的代谢和信号传导途径，从而使恶性细胞在不断变化的环境中适应并繁衍。在这篇综述中，我们着重于基质线粒体供应如何指导肿瘤线粒体，以及这种再教育如何维持肿瘤的恶性特征。