Objective:

Despite the staggering consequences of the opioid epidemic, limited nonopioid medication options have been developed to treat this medical and public health crisis. This study investigated the potential of cannabidiol (CBD), a nonintoxicating phytocannabinoid, to reduce cue-induced craving and anxiety, two critical features of addiction that often contribute to relapse and continued drug use, in drug-abstinent individuals with heroin use disorder.

Methods:

This exploratory double-blind randomized placebo-controlled trial assessed the acute (1 hour, 2 hours, and 24 hours), short-term (3 consecutive days), and protracted (7 days after the last of three consecutive daily administrations) effects of CBD administration (400 or 800 mg, once daily for 3 consecutive days) on drug cue–induced craving and anxiety in drug-abstinent individuals with heroin use disorder. Secondary measures assessed participants’ positive and negative affect, cognition, and physiological status.

Results:

Acute CBD administration, in contrast to placebo, significantly reduced both craving and anxiety induced by the presentation of salient drug cues compared with neutral cues. CBD also showed significant protracted effects on these measures 7 days after the final short-term (3-day) CBD exposure. In addition, CBD reduced the drug cue–induced physiological measures of heart rate and salivary cortisol levels. There were no significant effects on cognition, and there were no serious adverse effects.

Conclusions:

CBD’s potential to reduce cue-induced craving and anxiety provides a strong basis for further investigation of this phytocannabinoid as a treatment option for opioid use disorder.

中文翻译：

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卡纳比多二醇用于减少海洛因滥用药物戒断者的提示诱发的渴望和焦虑：双盲随机安慰剂对照试验。

客观的：

尽管阿片类药物流行带来了惊人的后果，但已经开发出了有限的非阿片类药物治疗方案来治疗这种医学和公共卫生危机。这项研究调查了无毒的植物大麻素大麻二酚（CBD）减少提示引起的渴望和焦虑的潜力，这是成瘾的两个关键特征，在成瘾的戒毒者中，成瘾的两个关键特征通常是导致复发和持续吸毒，而海洛因滥用的戒毒者则是如此。

方法：

这项探索性双盲随机安慰剂对照试验评估了下列药物的急性（1小时，2小时和24小时），短期（连续3天）和长期（连续3次每日给药后7天）的作用。在药物滥用引起的海洛因使用障碍患者中，由于药物提示引起的渴望和焦虑，对患者进行了CBD管理（400或800 mg，连续3天每天一次）。次要措施评估参与者的正面和负面影响，认知和生理状态。

结果：

与安慰剂相比，急性CBD给药与中性提示相比，显着减少了因药物提示明显而引起的渴望和焦虑。在最后一次短期（3天）CBD暴露后7天，CBD还显示出对这些措施的显着持久影响。此外，CBD还降低了药物提示引起的心率和唾液皮质醇水平的生理指标。对认知没有显着影响，也没有严重的不良影响。

结论：

CBD减少线索引起的渴望和焦虑的潜力为进一步研究这种植物大麻素作为阿片类药物使用障碍的治疗方法提供了坚实的基础。