Beyond their essential role in leukocyte homing in the context of inflammation, chemokines orchestrate the host response to cancer progression. Chemokines are key accelerators in the amplification of inflammatory signals and metastasis in the distal zone of tumors, indicating possible immune editing of tumor cells in the microenvironment. This review summarizes the main macrophage-attracting chemokines secreted from cancer cells and how these mediators can be targeted to improve cancer immunotherapy in multiple cancer types.

中文翻译：

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癌细胞分泌的巨噬细胞趋化因子：肿瘤微环境的雕刻家和癌症分泌基因组的另一个关键部分，可作为治疗靶标。

趋化因子除了在炎症环境中在白细胞归巢中起重要作用外，还可以协调宿主对癌症进展的反应。趋化因子是炎症信号放大和肿瘤远端区域转移的关键促进剂，表明在微环境中可能对肿瘤细胞进行免疫编辑。这篇综述总结了癌细胞分泌的主要吸引巨噬细胞的趋化因子，以及如何靶向这些介体以改善多种癌症类型的癌症免疫疗法。