BACKGROUND & AIMS Inflammatory bowel diseases (IBD) affect 200-400 people per 100,000 in the United States, about half of whom are women. We aimed to define the prevalence of vulvovaginal symptoms and association with IBD activity in a large cohort of women. METHODS Women more than 18 years old with IBD (1250) completed an online survey querying the presence and severity of vulvar or vaginal itch, burn, or irritation, vaginal discharge or dryness, and vulvovaginal pain. The survey collected information on demographic features and IBD activity (categorized using the Manitoba index). Women with and without symptoms were compared using bivariate analyses. Logistic regression evaluated associations between IBD severity and vulvovaginal symptoms, adjusted for diagnosis, menopause, smoking, depression, and use of medications to treat IBD. RESULTS A total of 512 (41%) women reported at least 1 moderate-severe vulvovaginal symptom. All vulvovaginal symptoms except vaginal dryness were more common in women with active IBD. In a multivariate model controlled for menopause, smoking, t-score from the PROMIS depression instrument, and use of IBD medications, women with constant or frequent active IBD, based on Manitoba index scores, had increased odds for moderate-severe vulvovaginal symptoms (odds ratio, 1.68; 95% CI, 1.22-2.32) compared to women in remission. Vulvovaginal discomfort frequently or always decreased interest in sex (n=336; 28%) or ability to have sex (n=207; 16%). CONCLUSIONS In an online survey of 1250 women, we found that women with more active IBD have increased prevalence of vulvovaginal discomfort, compared to women in remission. These symptoms affect sexual health.

中文翻译：

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外阴阴道不适与炎症性肠病活动之间的关联。

背景和目的 炎症性肠病 (IBD) 在美国每 100,000 人中有 200-400 人受到影响，其中约一半是女性。我们的目的是在一大群女性中确定外阴阴道症状的患病率以及与 IBD 活动的关联。方法 18 岁以上患有 IBD 的女性 (1250) 完成了一项在线调查，询问是否存在外阴或阴道瘙痒、烧伤或刺激、阴道分泌物或干燥以及外阴阴道疼痛。该调查收集了有关人口特征和 IBD 活动的信息（使用曼尼托巴指数分类）。使用双变量分析比较了有症状和无症状的女性。Logistic 回归评估 IBD 严重程度与外阴阴道症状之间的关联，并针对诊断、更年期、吸烟、抑郁和使用药物治疗 IBD 进行调整。结果 共有 512 (41%) 名女性报告了至少 1 种中重度外阴阴道症状。除了阴道干燥外，所有外阴阴道症状在患有活动性 IBD 的女性中更为常见。在控制更年期、吸烟、PROMIS 抑郁量表的 t 评分和 IBD 药物使用的多变量模型中，根据曼尼托巴指数评分，患有持续或频繁活动性 IBD 的女性出现中重度外阴阴道症状的几率（几率比率，1.68；95% CI，1.22-2.32）与缓解期女性相比。外阴阴道不适经常或总是降低对性的兴趣 (n=336; 28%) 或发生性行为的能力 (n=207; 16%)。结论 在对 1250 名女性进行的在线调查中，我们发现，与处于缓解期的女性相比，患有更活跃 IBD 的女性外阴阴道不适的患病率更高。这些症状会影响性健康。