当前位置: X-MOL 学术Med. Res. Rev. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Tissue engineering strategies combining molecular targets against inflammation and fibrosis, and umbilical cord blood stem cells to improve hampered muscle and skin regeneration following cleft repair.
Medicinal Research Reviews ( IF 13.3 ) Pub Date : 2019-05-18 , DOI: 10.1002/med.21594
Michaël Schreurs 1 , C Maarten Suttorp 1, 2 , Henricus A M Mutsaers 3 , Anne Marie Kuijpers-Jagtman 4 , Johannes W Von den Hoff 1, 2 , Edwin M Ongkosuwito 1 , Paola L Carvajal Monroy 5 , Frank A D T G Wagener 1, 2
Affiliation  

Cleft lip with or without cleft palate is a congenital deformity that occurs in about 1 of 700 newborns, affecting the dentition, bone, skin, muscles and mucosa in the orofacial region. A cleft can give rise to problems with maxillofacial growth, dental development, speech, and eating, and can also cause hearing impairment. Surgical repair of the lip may lead to impaired regeneration of muscle and skin, fibrosis, and scar formation. This may result in hampered facial growth and dental development affecting oral function and lip and nose esthetics. Therefore, secondary surgery to correct the scar is often indicated. We will discuss the molecular and cellular pathways involved in facial and lip myogenesis, muscle anatomy in the normal and cleft lip, and complications following surgery. The aim of this review is to outline a novel molecular and cellular strategy to improve musculature and skin regeneration and to reduce scar formation following cleft repair. Orofacial clefting can be diagnosed in the fetus through prenatal ultrasound screening and allows planning for the harvesting of umbilical cord blood stem cells upon birth. Tissue engineering techniques using these cord blood stem cells and molecular targeting of inflammation and fibrosis during surgery may promote tissue regeneration. We expect that this novel strategy improves both muscle and skin regeneration, resulting in better function and esthetics after cleft repair.

中文翻译:

组织工程学策略结合了针对炎症和纤维化的分子靶标以及脐带血干细胞,以改善improve裂修复后受阻碍的肌肉和皮肤再生。

有或没有without裂的唇裂是一种先天性畸形,发生于700名新生儿中的大约1名,影响了口面部的牙列,骨骼,皮肤,肌肉和粘膜。left裂会引起颌面部发育,牙齿发育,言语和进食问题,还可能导致听力障碍。嘴唇的手术修复可能会导致肌肉和皮肤的再生受损,纤维化和形成疤痕。这可能会导致面部发育受阻以及牙齿发育受阻,从而影响口腔功能以及嘴唇和鼻子的美观。因此,经常需要进行二次手术来纠正疤痕。我们将讨论与面部和嘴唇的肌发生,正常和唇裂的肌肉解剖以及手术后的并发症有关的分子和细胞途径。这篇综述的目的是概述一种新颖的分子和细胞策略,以改善肌肉组织和皮肤再生并减少reduce裂修复后的疤痕形成。可以通过产前超声检查在胎儿中诊断出颌面裂痕,并可以计划在出生时收获脐带血干细胞。使用这些脐带血干细胞的组织工程技术以及外科手术期间炎症和纤维化的分子靶向可促进组织再生。我们希望这种新颖的策略能够改善肌肉和皮肤的再生,从而在裂口修复后带来更好的功能和美观。可以通过产前超声检查在胎儿中诊断出颌面裂痕,并可以计划在出生时收获脐带血干细胞。使用这些脐带血干细胞的组织工程技术以及外科手术期间炎症和纤维化的分子靶向可促进组织再生。我们希望这种新颖的策略能够改善肌肉和皮肤的再生,从而在裂口修复后带来更好的功能和美观。可以通过产前超声检查在胎儿中诊断出颌面裂痕,并可以计划在出生时收获脐带血干细胞。使用这些脐带血干细胞的组织工程技术以及外科手术期间炎症和纤维化的分子靶向可促进组织再生。我们希望这种新颖的策略能够改善肌肉和皮肤的再生,从而在裂口修复后带来更好的功能和美观。
更新日期:2019-05-18
down
wechat
bug