Background

Previous studies indicate that circadian preference is associated with various energy metabolism and metabolic disorders. However, little is known about the associations between a circadian rhythm and blood lipid levels, especially in humans.

Objective

The aim of the study was to investigate whether the circadian rhythm affects serum lipid levels in Korean adults.

Methods

We designed a cross-sectional study to evaluate the associations between circadian preference and blood lipid levels in Korean adults. A total of 1984 participants (range of age 19–81 years) were included in this study. Propensity scores were calculated using logistic regression with age, sex, and body mass index. A total of 435 subjects were evaluated by propensity score matching analysis, equally distributed into morningness, intermediate, and eveningness groups, each with 145 subjects. Circadian preference was evaluated by the Morningness-Eveningness Questionnaire.

Results

Participants with the evening preference had significantly higher levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, and non–high-density lipoprotein cholesterol (non–HDL-C) when compared with those with morning or intermediate preference, after adjusting for confounding variables. Regarding other lipid parameters, both total cholesterol/HDL-C and low-density lipoprotein cholesterol/HDL-C in the evening preference are significantly higher than those of other circadian preferences. Evening preference was also significantly associated with a higher atherogenic index of plasma.

Conclusion

Our study demonstrates that there is a significant association between circadian preference and blood lipid levels. Our findings suggest that individuals with evening preference could have a greater risk of atherosclerotic cardiovascular diseases.

中文翻译：

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使用1：1：1倾向评分匹配分析，昼夜节律与血脂水平之间的关联。

背景

先前的研究表明，昼夜节律与各种能量代谢和代谢紊乱有关。然而，关于昼夜节律与血脂水平之间的相关性知之甚少，尤其是在人类中。

客观的

这项研究的目的是调查昼夜节律是否会影响韩国成年人的血脂水平。

方法

我们设计了一项横断面研究，以评估韩国成年人的昼夜节律与血脂水平之间的关联。这项研究总共包括1984名参与者（年龄在19-81岁之间）。使用年龄，性别和体重指数的逻辑回归计算倾向得分。通过倾向得分匹配分析对总共435名受试者进行了评估，并将其平均分配到早晨，中级和傍晚组，每组145名受试者。昼夜节律问卷由《晨间晚间问卷》评估。

结果

校正混杂因素后，与早晨或中度偏爱的参与者相比，夜间偏爱的参与者的总胆固醇，甘油三酸酯，低密度脂蛋白胆固醇和非高密度脂蛋白胆固醇（非HDL-C）水平显着更高变量。关于其他脂质参数，夜间偏爱的总胆固醇/ HDL-C和低密度脂蛋白胆固醇/ HDL-C均显着高于其他昼夜节律。晚上偏好也与血浆的更高的动脉粥样硬化指数显着相关。

结论

我们的研究表明，昼夜节律与血脂水平之间存在显着相关性。我们的研究结果表明，晚上偏爱的人患动脉粥样硬化性心血管疾病的风险可能更高。