The prevalence of multiple sclerosis (MS) is on the rise globally, and recent epidemiological studies have observed increased rates in the Arab world (i.e., countries of North Africa and the Middle East where Arabic is the primary language). However, assessment of cognitive impairment and its relevant covariates (e.g., fatigue and depressive symptomatology) in the Arab world has not been rigorously reviewed. Thus, the objective of the present study was to systematically review the current use of cognitive assessment measures in observational and interventional studies of individuals with MS in the Arab world. A systematic review of studies that assessed cognitive function in adults with MS in the Arab world was conducted using PubMed, PsycINFO, CINAHL, The Cochrane Library, Embase, WHO Global Index Medicus, and Ovid Global Health. Studies that featured at least one objective cognitive measure were included. Eligible studies were reviewed for bias and study quality using the QUADAS-2 and NIH QAT. Study characteristics and finding were extracted by two independent reviewers, with results confirmed by a third reviewer. A total of 13 (N = 846) studies met inclusion criteria. Risk of bias and included measures varied across studies. Results demonstrated inconsistent availability and use of MS cognitive assessment tools across the Arab world. An Arabic version of the BICAMS was the only cognitive battery that was evaluated with regard to psychometric properties. The most common individual test include in reviewed studies was the SDMT. However, validation studies are still needed for this and a number of other measures. Other measures are still in the early stages of translation and cultural-linguistic norming. This review of cognitive assessment of individuals with MS in the Arab world was limited by variable study quality and measure selection. The present review provides a summary of the tests most commonly used in this region and recommendations for future investigation.

中文翻译：

---

阿拉伯世界多发性硬化症患者的认知评估：系统评价。

全球多发性硬化症（MS）的患病率正在上升，最近的流行病学研究已经观察到阿拉伯世界（即以阿拉伯语为主要语言的北非和中东国家）的发病率有所上升。然而，阿拉伯世界对认知障碍及其相关协变量（例如疲劳和抑郁症状）的评估尚未得到严格审查。因此，本研究的目的是系统地回顾在阿拉伯世界的MS患者的观察性和介入性研究中认知评估方法的当前应用。使用PubMed，PsycINFO，CINAHL，Cochrane图书馆，Embase，WHO全球索引医学和Ovid全球健康，对评估阿拉伯世界成年人MS认知功能的研究进行了系统的综述。包括至少一项客观认知测量的研究。使用QUADAS-2和NIH QAT对符合条件的研究进行了偏倚和研究质量的审查。研究特征和发现由两名独立审稿人提取，结果由第三名审稿人确认。共13（ñ = 846）研究符合纳入标准。偏倚风险和纳入措施因研究而异。结果表明，在整个阿拉伯世界，MS认知评估工具的可用性和使用情况不一致。BICAMS的阿拉伯文版本是唯一针对心理测量特性进行评估的认知电池。在审查的研究中，最常见的个人测试是SDMT。但是，为此和许多其他措施仍需要进行验证研究。其他措施仍处于翻译和文化语言规范化的早期阶段。这项对阿拉伯世界MS患者的认知评估的综述受到可变的研究质量和措施选择的限制。本综述总结了该地区最常用的测试方法，并提出了进一步调查的建议。