Cell signaling controls essentially all cellular processes. While it is often assumed that proteins are the key architects coordinating cell signaling, recent studies have shown more and more clearly that lipids are also involved in signaling processes in a number of ways. Lipids do, for instance, act as messengers, modulate membrane receptor conformation and dynamics, and control membrane receptor partitioning. Further, through structural modifications such as oxidation, the functions of lipids as part of signaling processes can be modified. In this context, in this article we discuss the understanding recently revealed by atomistic and coarse-grained computer simulations of nanoscale processes and underlying physicochemical principles related to lipids' functions in cellular signaling.

中文翻译：

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通过细胞膜的原子和多尺度模拟了解脂质在信号传导中的作用。

细胞信号传导基本上控制所有细胞过程。人们通常认为蛋白质是协调细胞信号传导的关键结构，但最近的研究越来越清楚地表明，脂质也以多种方式参与信号传导过程。脂质例如充当信使，调节膜受体的构象和动力学，并控制膜受体的分配。此外，通过诸如氧化的结构修饰，可以修饰脂质作为信号传导过程的一部分的功能。在这种情况下，我们将在本文中讨论最近通过原子级和粗粒度计算机模拟对纳米级过程以及与脂质在细胞信号传导中的功能有关的潜在理化原理的计算机模拟所揭示的理解。