Wound healing, tissue regeneration, and organ regrowth are all regeneration phenomena observed in vertebrates after an injury. However, the ability to regenerate differs greatly among species. Mammals can undergo wound healing and tissue regeneration, but cannot regenerate an organ; for example, they cannot regrow an amputated limb. In contrast, amphibians and fish have much higher capabilities for organ-level regeneration. In addition to medical studies and those in conventional mammalian models such as mice, studies in amphibians and fish have revealed essential factors for and mechanisms of regeneration, including the regrowth of a limb, tail, or fin. However, the molecular nature of the cellular memory needed to precisely generate a new appendage from an amputation site is not fully understood. Recent reports have indicated that organ regeneration is closely related to epigenetic regulation. For example, the methylation status of genomic DNA is related to the expression of regeneration-related genes, and histone-modification enzymes are required to control the chromatin dynamics for regeneration. A proposed mechanism of cellular memory involving an inheritable system of epigenetic modification led us to hypothesize that epigenetic regulation forms the basis for cellular memory in organ regeneration. Here we summarize the current understanding of the role of epigenetic regulation in organ regeneration and discuss the relationship between organ regeneration and epigenetic memory.

中文翻译：

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脊椎动物肢体精确再生所依据的染色质动力学-表观遗传调控和细胞记忆。

伤口愈合，组织再生和器官再生都是受伤后在脊椎动物中观察到的再生现象。但是，不同物种之间的再生能力差异很大。哺乳动物可以进行伤口愈合和组织再生，但是不能再生器官。例如，他们不能使截肢的人再生。相反，两栖动物和鱼类具有更高的器官水平再生能力。除了医学研究以及常规哺乳动物模型（例如小鼠）的研究之外，对两栖动物和鱼类的研究还揭示了再生的重要因素和机理，包括肢体，尾巴或鳍的再生。但是，从截肢部位精确产生新的附属物所需的细胞记忆的分子性质尚未完全了解。最近的报道表明器官再生与表观遗传调控密切相关。例如，基因组DNA的甲基化状态与再生相关基因的表达有关，并且需要组蛋白修饰酶来控制用于再生的染色质动力学。涉及表观遗传修饰的可遗传系统的细胞记忆的拟议机制使我们假设表观遗传调控形成器官再生中细胞记忆的基础。在这里，我们总结了目前对表观遗传调控在器官再生中的作用的理解，并讨论了器官再生与表观遗传记忆之间的关系。需要使用组蛋白修饰酶来控制染色质动力学以再生。涉及表观遗传修饰的可遗传系统的细胞记忆的拟议机制使我们假设表观遗传调控形成器官再生中细胞记忆的基础。在这里，我们总结了目前对表观遗传调控在器官再生中的作用的理解，并讨论了器官再生与表观遗传记忆之间的关系。需要使用组蛋白修饰酶来控制染色质动力学以再生。涉及表观遗传修饰的可遗传系统的细胞记忆的拟议机制使我们假设表观遗传调控形成器官再生中细胞记忆的基础。在这里，我们总结了目前对表观遗传调控在器官再生中的作用的理解，并讨论了器官再生与表观遗传记忆之间的关系。