BACKGROUND Relapse risk during the early years of first-episode psychosis (FEP) considerably increases the risk of chronicity. The effectiveness of family intervention for psychosis (FIp) for preventing relapse after FEP remains unknown. We assessed the effectiveness of FIp until 24 months of follow-up for preventing relapse and other relapse-related outcomes in patients following FEP. METHODS We searched the Cochrane, PubMed, PsycINFO, and ProQuest databases in June 2018. A systematic review with meta-analysis of randomized controlled trials (RCTs), sensitivity analyses, and publication bias were performed, comparing to treatment as usual (TAU) or TAU plus other psychosocial interventions. Outcomes assessed were relapse rates, duration of hospitalization, psychotic symptoms, and functionality. Risk ratios (RRs) and (standardized) mean differences (SMD; MD) were calculated. RESULTS Of the 2109 records retrieved, 14 (11 RCTs) were included. Pooled results showed that FIp was effective for preventing relapse (RR = 0.42; 95% CI = 0.29 to 0.61) compared to TAU and/or other psychosocial interventions. It also proved effective when compared to TAU alone (RR = 0.36) and TAU plus other psychosocial interventions (RR = 0.48). FIp showed benefits in reducing duration of hospitalization (TAU, MD = -3.31; other interventions, MD = -4.57) and psychotic symptoms (TAU, SMD = -0.68), and increased functionality (TAU, SMD = 1.36; other interventions, SMD = 1.41). CONCLUSIONS These findings suggest that FIp is effective for reducing relapse rates, duration of hospitalization, and psychotic symptoms, and for increasing functionality in FEP patients up to 24 months. The study's main limitations were the inclusion of published research only; authors were not contacted for missing/additional data; and high heterogeneity regarding relapse definition was observed.

中文翻译：

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直到24个月的随访，家庭干预预防初发性精神病复发的有效性：一项系统评价，随机对照试验的荟萃分析。

背景技术在首发性精神病（FEP）的早期，复发风险会大大增加慢性病的风险。家庭干预精神病（FIp）预防FEP后复发的有效性仍然未知。我们评估了FIp的有效性，直到随访24个月，以预防FEP后患者的复发和其他与复发相关的结局。方法我们于2018年6月搜索了Cochrane，PubMed，PsycINFO和ProQuest数据库。与常规治疗（TAU）或TAU和其他社会心理干预措施。评估的结果是复发率，住院时间，精神病症状和功能。计算风险比（RRs）和（标准化）平均差异（SMD； MD）。结果在检索到的2109条记录中，包括了14条（11条RCT）。汇总结果显示，与TAU和/或其他社会心理干预措施相比，FIp可有效预防复发（RR = 0.42； 95％CI = 0.29至0.61）。与单独使用TAU（RR = 0.36）和TAU加其他社会心理干预措施（RR = 0.48）相比，它也被证明是有效的。FIp在减少住院时间（TAU，MD = -3.31;其他干预措施，MD = -4.57）和精神病症状（TAU，SMD = -0.68）和功能增强（TAU，SMD = 1.36;其他干预措施，SMD）方面显示出益处= 1.41）。结论这些发现表明FIp可有效降低复发率，住院时间和精神病性症状，并在长达24个月的时间内提高FEP患者的功能。这项研究的主要局限性是仅包括已发表的研究。没有联系作者以获取丢失/其他数据；并且观察到关于复发定义的高度异质性。