BACKGROUND & AIMS Obesity has been associated with an increased risk of colonic diverticulosis. Evidence for this association is limited. We assessed whether anthropometric measures of obesity were associated with colonic diverticulosis. METHODS We analyzed data from a prospective study of 623 patients undergoing screening colonoscopies from 2013 through 2015; colonoscopies included examinations for diverticulosis. Body measurements were made the day of the procedure. Multivariate analyses were performed using modified Poisson regression to estimate prevalence ratios (PRs) and 95% CIs while adjusting for confounding variables. All analyses were stratified by sex. RESULTS Among men, there was no association between any measure of obesity and diverticulosis. After adjustment, women with an obese body mass index (BMI ≥ 30) had an increased risk of any diverticulosis (PR, 1.48; 95% CI, 1.08-2.04) compared with women with a normal body mass index (BMI 18.5-24.9). The strength of this association was greater for more than 5 diverticula (PR, 2.05; 95% CI, 1.23-3.40). There was no significant association between measures of central obesity and diverticulosis in women. Stratified by sex, colonic diverticulosis was significantly less prevalent in women compared with men before the age of 51 years (29% vs 45%, P = .06). The prevalence of diverticulosis did not differ by sex in older age groups. CONCLUSIONS In an analysis of data from 623 patients undergoing screening colonoscopies, we found that obesity (BMI ≥30) significantly increased the risk of colonic diverticulosis in women but not men. Colonic diverticulosis was less prevalent in premenopausal-age women compared with similar-age men. These findings suggest that sex hormones may influence the development of diverticulosis.

中文翻译：

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肥胖与妇女结肠憩室的关系。

背景与目的肥胖与结肠憩室病风险增加有关。这种关联的证据是有限的。我们评估了肥胖症的人体测量指标是否与结肠憩室有关。方法我们分析了2013年至2015年对623例接受结肠镜检查筛查的患者进行的前瞻性研究数据。结肠镜检查包括憩室检查。在手术当天进行身体测量。使用修正的Poisson回归进行多变量分析，以估计患病率（PR）和95％CI，同时调整混杂变量。所有分析均按性别分层。结果在男性中，肥胖与憩室的任何度量之间均无关联。调整后 体重指数（BMI≥30）的女性与正常体重指数（BMI 18.5-24.9）的女性发生憩室憩室病的风险增加（PR，1.48; 95％CI，1.08-2.04）。对于超过5个憩室，这种关联的强度更高（PR，2.05； 95％CI，1.23-3.40）。妇女的中枢性肥胖与憩室病之间没有显着相关性。按性别分层，女性结肠结肠憩室病的发生率明显低于51岁之前的男性（29％比45％，P = .06）。在老年人群中，憩室病的患病率在性别上没有差异。结论在对623例接受结肠镜检查筛查的患者的数据进行的分析中，我们发现肥胖（BMI≥30）显着增加了女性而非男性的结肠憩室病风险。与同龄男性相比，绝经前女性的结肠憩室病患病率较低。这些发现表明性激素可能会影响憩室的发展。