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Dental remineralization via poly(amido amine) and restorative materials containing calcium phosphate nanoparticles.
International Journal of Oral Science ( IF 14.9 ) Pub Date : 2019-05-09 , DOI: 10.1038/s41368-019-0048-z
Kunneng Liang 1, 2 , Suping Wang 2, 3 , Siying Tao 1 , Shimeng Xiao 1, 2 , Han Zhou 2 , Ping Wang 2 , Lei Cheng 1, 2 , Xuedong Zhou 1 , Michael D Weir 2 , Thomas W Oates 2 , Jiyao Li 1 , Hockin H K Xu 2, 4, 5
Affiliation  

Tooth decay is prevalent, and secondary caries causes restoration failures, both of which are related to demineralization. There is an urgent need to develop new therapeutic materials with remineralization functions. This article represents the first review on the cutting edge research of poly(amido amine) (PAMAM) in combination with nanoparticles of amorphous calcium phosphate (NACP). PAMAM was excellent nucleation template, and could absorb calcium (Ca) and phosphate (P) ions via its functional groups to activate remineralization. NACP composite and adhesive showed acid-neutralization and Ca and P ion release capabilities. PAMAM+NACP together showed synergistic effects and produced triple benefits: excellent nucleation templates, superior acid-neutralization, and ions release. Therefore, the PAMAM+NACP strategy possessed much greater remineralization capacity than using PAMAM or NACP alone. PAMAM+NACP achieved dentin remineralization even in an acidic solution without any initial Ca and P ions. Besides, the long-term remineralization capability of PAMAM+NACP was established. After prolonged fluid challenge, the immersed PAMAM with the recharged NACP still induced effective dentin mineral regeneration. Furthermore, the hardness of pre-demineralized dentin was increased back to that of healthy dentin, indicating a complete remineralization. Therefore, the novel PAMAM+NACP approach is promising to provide long-term therapeutic effects including tooth remineralization, hardness increase, and caries-inhibition capabilities.

中文翻译:

通过聚(酰胺基胺)和含有磷酸钙纳米粒子的修复材料进行牙齿再矿化。

蛀牙是普遍的,继发性龋齿导致修复失败,这两者都与脱矿质有关。迫切需要开发具有矿化功能的新型治疗材料。本文代表了关于聚(酰胺基胺)(PAMAM)与无定形磷酸钙(NACP)纳米粒子结合的前沿研究的第一篇综述。PAMAM是出色的成核模板,并且可以通过其官能团吸收钙(Ca)和磷酸(P)离子来激活再矿化。NACP复合材料和胶粘剂具有中和酸和释放Ca和P离子的能力。PAMAM + NACP共同显示出协同作用,并产生了三重好处:出色的成核模板,优异的酸中和能力和离子释放能力。所以,与单独使用PAMAM或NACP相比,PAMAM + NACP策略具有更大的再矿化能力。即使在无任何初始Ca和P离子的酸性溶液中,PAMAM + NACP也能实现牙本质再矿化。此外,还建立了PAMAM + NACP的长期再矿化能力。长时间的体液刺激后,浸没的PAMAM与重新充电的NACP仍可诱导有效的牙本质矿物质再生。此外,脱矿质牙本质的硬度增加到健康牙本质的硬度,表明完全再矿化。因此,新颖的PAMAM + NACP方法有望提供长期的治疗效果,包括牙齿再矿化,硬度增加和龋齿抑制能力。即使在无任何初始Ca和P离子的酸性溶液中,PAMAM + NACP也能实现牙本质再矿化。此外,还建立了PAMAM + NACP的长期再矿化能力。长时间的液体刺激后,浸没的PAMAM与重新充电的NACP仍可诱导有效的牙本质矿物质再生。此外,脱矿质牙本质的硬度增加到健康牙本质的硬度,表明完全再矿化。因此,新颖的PAMAM + NACP方法有望提供长期的治疗效果,包括牙齿再矿化,硬度增加和龋齿抑制能力。即使在无任何初始Ca和P离子的酸性溶液中,PAMAM + NACP也能实现牙本质再矿化。此外,还建立了PAMAM + NACP的长期再矿化能力。长时间的液体刺激后,浸没的PAMAM与重新充电的NACP仍可诱导有效的牙本质矿物质再生。此外,脱矿质牙本质的硬度增加到健康牙本质的硬度,表明完全再矿化。因此,新颖的PAMAM + NACP方法有望提供长期的治疗效果,包括牙齿再矿化,硬度增加和龋齿抑制能力。浸没的PAMAM和再充电的NACP仍可诱导有效的牙本质矿物质再生。此外,脱矿质牙本质的硬度增加到健康牙本质的硬度,表明完全再矿化。因此,新颖的PAMAM + NACP方法有望提供长期的治疗效果,包括牙齿再矿化,硬度增加和龋齿抑制能力。浸没的PAMAM和再充电的NACP仍可诱导有效的牙本质矿物质再生。此外,脱矿质牙本质的硬度增加到健康牙本质的硬度,表明完全再矿化。因此,新颖的PAMAM + NACP方法有望提供长期的治疗效果,包括牙齿再矿化,硬度增加和龋齿抑制能力。
更新日期:2019-05-09
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