Alternative splicing is critical for human gene expression regulation, which plays a determined role in expanding the diversity of functional proteins. Importantly, alternative splicing is a hallmark of cancer and a potential target for cancer therapeutics. Based on the statistical data, breast cancer is one of the top leading causes of cancer-related deaths in women worldwide. Strikingly, alternative splicing is closely associated with breast cancer development. Here, we seek to provide a general review of the relationship between alternative splicing and breast cancer. We introduce the process of alternative splicing and its regulatory role in cancers. In addition, we highlight the functions of aberrant alternative splicing and mutations of splicing factors in breast cancer progression. Moreover, we discuss the role of alternative splicing in cancer drug resistance and the potential of being targets for cancer therapeutics.

中文翻译：

---

乳腺癌中的异常替代性剪接。

选择性剪接对于人类基因表达调控至关重要，人类基因表达调控在扩大功能蛋白的多样性中起着确定的作用。重要的是，选择性剪接是癌症的标志，也是癌症治疗的潜在靶标。根据统计数据，乳腺癌是全世界女性与癌症相关的死亡的最主要原因之一。引人注目的是，选择性剪接与乳腺癌的发展密切相关。在这里，我们寻求对替代剪接与乳腺癌之间的关系进行一般性综述。我们介绍了选择性剪接的过程及其在癌症中的调控作用。此外，我们重点介绍了异常替代剪接的功能和剪接因子的突变在乳腺癌进展中的作用。而且，