Microchannels are simple, perfusable architectural features engineered into biomaterials to promote mass transport of solutes to cells, effective cell seeding and compartmentalisation for tissue engineering applications, control over spatiotemporal distribution of molecules and ligands, and survival, integration, and vascularisation of engineered tissue analogues in vivo. Advances in biofabrication have led to better control over microchannel fabrication in 3D scaffolds, enabling sophisticated designs that drive the development of complex tissue structures. This review addresses the importance of microchannel structures in biomaterial design and regenerative medicine, and discusses their function, fabrication methods, and proposed mechanisms underlying their effects.

微通道简单，可灌注的建筑特色工程化到生物材料，以促进溶质的质量传送到细胞中，有效的细胞接种和区室用于组织工程应用，经分子和配体，和存活，集成的时空分布控制，和工程化组织类似物的血管形成在体内。生物制造技术的进步已导致对3D支架中微通道制造的更好控制，从而实现了驱动复杂组织结构发展的复杂设计。这篇综述解决了微通道结构在生物材料设计和再生医学中的重要性，并讨论了它们的功能，制造方法以及潜在影响其作用的机制。