MRI contrast agents (CAs) feature coordinated water molecule(s) (aqua ligands), which renders them unsuitable for magnetic resonance (MR) temperature mapping because of their resulting sensitivity to metabolic and physiological changes and/or their tendency to release toxic Gd³⁺ cations. Herein, we introduce an approach to temperature mapping based upon a coordinatively saturated gadolinium (Gd)-based metal-organic framework (MOF) that exhibits enhanced proton relaxation and high temperature sensitivity. The stable, non-toxic Gd zeolite-like MOF Gd-ZMOF was observed to generate a large enhancement in contrast as a result of a large (70%) contribution from second-sphere water relaxivity. Temperature mapping by clinical CAs and Gd-ZMOF by means of longitudinal (T₁) relaxivity was investigated. Gd-ZMOF enabled the visualization of small temperature changes, especially in the thermal therapy region (41°C–45°C). In vivo thermal imaging demonstrates the feasibility of Gd-ZMOF as an MR thermometer and as a potential theranostic.

MRI造影剂（CA）具有协调的水分子（水配体），由于它们对代谢和生理变化的敏感性和/或它们释放有毒Gd ³的趋势，因此使其不适合进行磁共振（MR）温度作图。⁺阳离子。在本文中，我们介绍了一种基于协同饱和saturated（Gd）的金属有机框架（MOF）进行温度映射的方法，该方法显示出增强的质子弛豫和高温敏感性。观察到稳定的，无毒的类似Gd沸石的MOF Gd-ZMOF产生了很大的反差，这是由于第二层水弛豫性的贡献很大（70％）。通过临床CA和Gd-ZMOF进行温度作图通过纵向（T ₁）弛豫性进行了研究。Gd-ZMOF可以观察到小的温度变化，尤其是在热疗区域（41°C–45°C）中。体内热成像证明了Gd-ZMOF作为MR温度计和潜在的治疗方法的可行性。