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Adherence to the Dietary Approaches to Stop Hypertension (DASH) diet and risk of total and cause-specific mortality: results from the Golestan Cohort Study.
International Journal of Epidemiology ( IF 7.7 ) Pub Date : 2019-12-01 , DOI: 10.1093/ije/dyz079
Zeinab Mokhtari 1 , Maryam Sharafkhah 1 , Hossein Poustchi 2 , Sadaf G Sepanlou 3 , Masoud Khoshnia 1, 4 , Abdolsamad Gharavi 1, 4 , Amir Ali Sohrabpour 2 , Masoud Sotoudeh 1, 2, 3 , Sanford M Dawsey 5 , Paolo Boffetta 6 , Christian C Abnet 5 , Farin Kamangar 1, 7 , Arash Etemadi 1, 5 , Akram Pourshams 1 , Akbar FazeltabarMalekshah 1 , Farhad Islami 1, 8 , Paul Brennan 9 , Reza Malekzadeh 1 , Azita Hekmatdoost 10, 11
Affiliation  

OBJECTIVE To evaluate the association between adherence to the Dietary Approaches to Stop Hypertension (DASH) diet and overall and cause-specific mortality in the Golestan Cohort Study (GCS). METHODS A total of 50 045 participants aged 40 years or older were recruited from Golestan Province, Iran, from 2004 to 2008 and followed for a mean of 10.64 years. The DASH diet score was calculated for each individual based on food groups. The primary outcome measure was death from any cause. RESULTS During 517 326 person-years of follow-up, 6763 deaths were reported. After adjustment for potential confounders, DASH diet score was inversely associated with risk of death from all causes and cancers [hazard ratio (HR): 0.86; 95% confidence interval (CI): 0.75, 0.98; and HR: 0.65; 95% CI: 0.47, 0.90, respectively]. A higher DASH diet score was associated with lower risk of gastrointestinal cancer mortality in men (HR: 0.55; 95% CI: 0.30, 0.99). A greater adherence to DASH diet was also associated with lower other-cancer mortality in women (HR: 0.50; 95% CI: 0.24, 0.99). No association between DASH diet score and cardiovascular disease mortality was observed, except that those dying of cardiovascular disease were younger than 50 years of age and smokers. CONCLUSIONS Our findings suggest that maintaining a diet similar to the DASH diet is independently associated with reducing the risk of total death, cancers, and especially gastrointestinal cancers in men.

中文翻译:

遵守停止高血压(DASH)饮食的饮食方法以及总死亡率和特定原因死亡的风险:Golestan Cohort研究的结果。

目的在Golestan队列研究(GCS)中评估坚持饮食的方法以停止高血压(DASH)饮食与总体死亡率和特定原因死亡率之间的关联。方法2004年至2008年,共从伊朗Golestan省招募了50 045名40岁以上的参与者,平均随访10.64年。根据食物组别计算每个人的DASH饮食分数。主要结局指标是因任何原因导致的死亡。结果在517326人-年的随访中,报告了6763人死亡。在对潜在的混杂因素进行调整后,DASH饮食评分与所有原因和癌症的死亡风险成反比[危险比(HR):0.86;95%置信区间(CI):0.75,0.98; HR:0.65;95%CI:分别为0.47和0.90]。较高的DASH饮食评分与男性胃肠道癌死亡的风险较低相关(HR:0.55; 95%CI:0.30,0.99)。坚持使用DASH饮食还可以降低女性的其他癌症死亡率(HR:0.50; 95%CI:0.24,0.99)。DASH饮食评分与心血管疾病死亡率之间没有相关性,只是死于心血管疾病的人年龄小于50岁且吸烟者除外。结论我们的研究结果表明,维持与DASH饮食相似的饮食与降低男性完全死亡,癌症,尤其是胃肠道癌症的风险相关。24,0.99)。DASH饮食评分与心血管疾病死亡率之间没有相关性,只是死于心血管疾病的人年龄小于50岁且吸烟者除外。结论我们的研究结果表明,维持与DASH饮食相似的饮食与降低男性完全死亡,癌症,尤其是胃肠道癌症的风险相关。24,0.99)。DASH饮食评分与心血管疾病死亡率之间没有相关性,只是死于心血管疾病的人年龄小于50岁且吸烟者除外。结论我们的研究结果表明,维持与DASH饮食相似的饮食与降低男性总死亡,癌症,尤其是胃肠道癌症的风险具有独立的关系。
更新日期:2019-12-25
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