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Designing circulating tumor DNA-based interventional clinical trials in oncology.
Genome Medicine ( IF 12.3 ) Pub Date : 2019-04-19 , DOI: 10.1186/s13073-019-0634-x
Daniel V Araujo 1 , Scott V Bratman 2 , Lillian L Siu 1
Affiliation  

Circulating tumor (ct) DNA is a powerful tool that can be used to track cancer beyond a single snapshot in space and time. It has potential applications in detecting minimal residual disease and predicting relapse, in selecting patients for tailored treatments, and in revealing mechanisms of response or resistance. Here, we discuss the incorporation of ctDNA into clinical trials.

中文翻译:

设计基于循环肿瘤DNA的肿瘤介入临床试验。

循环肿瘤(ct)DNA是一种功能强大的工具,可用于在空间和时间上超越单个快照来跟踪癌症。它在检测最小残留疾病和预测复发,选择患者进行量身定制的治疗以及揭示反应或耐药机制方面具有潜在的应用。在这里,我们讨论将ctDNA纳入临床试验。
更新日期:2019-04-19
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