Biochimica et Biophysica Acta (BBA) - Reviews on Cancer ( IF 11.2 ) Pub Date : 2019-05-03 , DOI: 10.1016/j.bbcan.2019.05.001 Cheng-Bei Zhou , Jing-Yuan Fang
Pyroptosis, a type of inflammatory programmed cell death, is mediated by multiple inflammasomes which can recognize danger signals and activate the secretion of pro-inflammatory cytokines like IL-181 and IL-1β2. It can induce cancer cell death within the gastrointestinal tract. NLRs3, AIM24, GSDM5 family play important roles in pyroptosis signaling pathways in intestinal cancer such as gastric cancer, colitis-associated colorectal cancer and esophageal cancer, etc. Furthermore, several inflammasomes are elucidated to be involved in mucosal innate immune responses and modulate specific enteric pathogens infection. Precise modulation of inflammasome activation and exploration of potential diagnostic markers can contribute to the diagnosis, prevention and treatment of intestinal tumors and inflammatory or infectious disorders in human patients in the near future.
中文翻译:
凋亡在胃肠道癌症中的作用以及对肠道微生物感染的免疫反应
Pyroptosis,类型炎性细胞程序性死亡的,由多个inflammasomes能够识别危险信号并激活促炎性细胞因子的分泌,如IL-18介导的1和IL-1β 2。它可以诱导胃肠道内的癌细胞死亡。NLRs 3,AIM2 4,GSDM 5家族在诸如胃癌,结肠炎相关的大肠癌和食道癌等肠癌的热信号通路中起重要作用。。此外,阐明了一些炎性小体参与了粘膜固有免疫反应并调节了特异性肠病原体的感染。炎性体激活的精确调节和潜在诊断标记的探索可在不久的将来为人类患者的肠道肿瘤和炎性或感染性疾病的诊断,预防和治疗做出贡献。