Epigenetic regulation of gene expression is fundamental in the maintenance of cellular identity and the regulation of cellular plasticity during tissue repair. In fact, epigenetic modulation is associated with the processes of cellular de-differentiation, proliferation, and re-differentiation that takes place during tissue regeneration. In here we explore the epigenetic events that coordinate tissue repair in lower vertebrates with high regenerative capacity, and in mammalian adult stem cells, which are responsible for the homeostasis maintenance of most of our tissues. Finally we summarize promising CRISPR-based editing technologies developed during the last years, which look as promising tools to not only study but also promote specific events during tissue regeneration.

中文翻译：

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量身定制的染色质调节可促进组织再生。

基因表达的表观遗传学调控是维持细胞身份和组织修复过程中细胞可塑性的基础。实际上，表观遗传调控与组织再生过程中发生的细胞去分化，增殖和再分化过程有关。在这里，我们探索表观遗传学事件，这些事件协调具有较高再生能力的低等脊椎动物和哺乳动物成体干细胞中的组织修复，而成年干细胞负责维持我们大多数组织的体内平衡。最后，我们总结了近几年发展起来的有前途的基于CRISPR的编辑技术，这些技术不仅在组织再生过程中还可以研究和促进特定事件，因此有望成为有前途的工具。