Synaptotagmins (Syts) are well-established primary Ca2+ sensors to initiate presynaptic neurotransmitter release. They also play critical roles in the docking, priming, and fusion steps of exocytosis, as well as the tightly coupled exo-endocytosis, in presynapses. A recent study by Awasthi and others (2019) shows that Syt3 Ca2+-dependently modulates the postsynaptic receptor endocytosis and thereby promotes the long-term depression (LTD) and the decay of long-term potentiation (LTP). This work highlights the importance of Syt3 in modulating long-term synaptic plasticity and, importantly, extends the function of Syt proteins from presynaptic neurotransmitter release to a new promising postsynaptic receptor internalization.

中文翻译：

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突触素：超越突触前神经递质的释放。

突触标记素（Syts）是公认的主要Ca2 +传感器，可启动突触前神经递质的释放。它们在突触前的胞吐作用的对接，引发和融合步骤以及紧密结合的胞吞作用中也起着关键作用。Awasthi等人（2019）的最新研究表明，Syt3 Ca2 +依赖地调节突触后受体的胞吞作用，从而促进长期抑制（LTD）和长期增强（LTP）的衰减。这项工作突出了Syt3在调节长期突触可塑性中的重要性，并且重要地，将Syt蛋白的功能从突触前神经递质释放扩展到新的有希望的突触后受体内在化。