Memory failure is a common clinical concern of patients with epilepsy and is associated with significant functional impairments. Thus, memory rehabilitation is of critical clinical importance. In this article, we aimed to systematically evaluate the efficacy of memory rehabilitation in patients with epilepsy. The Preferred Items for Systematic Reviews and Meta-Analyses (PRISMA) was used to guide searches, extraction and reporting of data in this review. PsycINFO, Medline and PsychBITE searches yielded 95 studies. Twelve papers met inclusion criteria, reporting outcomes of cognitive or behavioural interventions that specifically targeted the rehabilitation of memory in patients with epilepsy. Methodological rigour was rated using the Single-Case Experimental Design (SCED) scale for single-case studies and a modified version of the Downs and Black checklist for group studies. Twelve prospective studies, nine group (six pre-post design, one waitlist crossover, two randomised controlled trials) and three single-case studies were identified. Eleven of the studies included adults, eight of which involved adults with temporal lobe epilepsy (TLE). One paediatric study was identified. The quality of group studies ranged from 36% (poor) to 72% (good), using the modified Downs and Black checklist. Single-case studies were assessed using the SCED scale and assessed to range in quality from four to seven out to 11. Overall, memory rehabilitation was associated with improved memory function in all studies. Verbal memory outcomes were most commonly examined and associated with improvements. This review found that the level of evidence available to support rehabilitation of memory in patients with epilepsy was generally weak and inconsistent. Nevertheless, studies conducted to date, albeit of limited methodological quality, offer preliminary evidence that memory rehabilitation is associated with improvements in verbal memory in patients with temporal lobe epilepsy. Little is known about the efficacy of memory rehabilitation in patients with non-TLE, children, and other aspects of memory difficulties. Guidelines for future research are proposed.

中文翻译：

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癫痫患者的记忆修复：系统评价

记忆力衰竭是癫痫患者常见的临床问题，并伴有严重的功能障碍。因此，记忆康复在临床上具有至关重要的意义。在本文中，我们旨在系统地评估癫痫患者记忆力恢复的疗效。系统评价和荟萃分析的首选项目（PRISMA）用于指导该评价中数据的搜索，提取和报告。PsycINFO，Medline和PsychBITE搜索产生了95个研究。十二篇符合入选标准的论文报道了针对癫痫患者记忆康复的认知或行为干预的结果。使用单例实验设计（SCED）量表对单例研究进行了严格的方法学评估，对分组研究使用了Downs and Black清单的修改版本。确定了十二项前瞻性研究，九组（六个后期设计，一个候补名单交叉，两个随机对照试验）和三个单例研究。其中的11项研究包括成人，其中8项涉及颞叶癫痫（TLE）的成年人。确定了一项儿科研究。使用修改后的Downs and Black清单，小组研究的质量从36％（差）到72％（好）不等。单例研究使用SCED量表进行评估，评估的质量范围从4到7到11。总体而言，在所有研究中，记忆力恢复与记忆功能改善相关。言语记忆结果最常被检查并与改善相关。这项审查发现，可用于支持癫痫患者记忆力恢复的证据水平通常较弱且不一致。尽管如此，迄今为止进行的研究尽管方法学质量有限，但仍提供了初步的证据表明记忆恢复与颞叶癫痫患者的言语记忆改善有关。对于非TLE，儿童和其他记忆障碍患者的记忆康复功效知之甚少。提出了未来研究的指南。迄今为止进行的研究，尽管方法学质量有限，但提供了初步的证据表明记忆恢复与颞叶癫痫患者的言语记忆改善有关。对于非TLE，儿童和其他记忆障碍患者的记忆康复功效知之甚少。提出了未来研究的指南。迄今为止进行的研究，尽管方法学质量有限，但提供了初步的证据表明记忆恢复与颞叶癫痫患者的言语记忆改善有关。对于非TLE，儿童和其他记忆障碍患者的记忆康复功效知之甚少。提出了未来研究的指南。