Covering: Up to March 2019 Secondary metabolites (SMs) are chemical entities produced by organisms in response to environmental stimuli and as a defense against biological warfare. The production of SMs is controlled by a hierarchical regulatory network involving core factors that orchestrate transcriptional activation of SM gene clusters. In the past few years, significant achievements have been made in the discovery of novel fungal natural products by genetic manipulations of various types of transcriptional regulators. In this review, we summarized the representative regulators for the activation of fungal secondary metabolism and focused on the strategies for the exploitation of these regulators and their application in finding novel structures.

中文翻译：

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利用各种转录调节因子在真菌中发现天然产物。

涵盖范围：截至2019年3月，次生代谢物（SMs）是生物体响应环境刺激并抵御生物战而产生的化学实体。SM的产生是由涉及核心因素的分级调节网络控制的，该核心因素协调SM基因簇的转录激活。在过去的几年中，通过各种类型的转录调节因子的基因操作，在发现新颖的真菌天然产物方面已经取得了重大成就。在这篇综述中，我们总结了代表真菌次级代谢激活的调节剂，并着重于这些调节剂的开发策略及其在寻找新结构中的应用。