Bladder cancer is the fourth most common cancer in men and one of the most significant causes of cancer-related death worldwide, with transitional cell carcinoma (TCC) being the predominant form (representing 90% of cases).^1,2 The superficial or nonmuscle-invasive TCCs, which could be managed by transurethral resection, tend to recur or progress.³ The advanced or muscle-invasive TCCs are associated with a high risk of death from distant metastases.⁴ Because of the lack of suitable diagnostic biomarkers and effective therapies, patients are often diagnosed at advanced stages and the mortality rate keeps increasing.⁵ Considering these issues, it is essential to study TCCs at the genetic level to characterize the targeted agents.

中文翻译：

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Gelsolin 样肌动蛋白帽蛋白具有预后价值并通过 Hippo 信号通路促进人膀胱癌的肿瘤发生和上皮间质转化

膀胱癌是男性第四大常见癌症，也是全球癌症相关死亡的最重要原因之一，其中移行细胞癌 (TCC) 是主要形式（占病例的 90%）。^1,2可以通过经尿道切除治疗的浅表或非肌肉浸润性 TCC 往往会复发或进展。³晚期或肌肉浸润性 TCC 与远处转移的高死亡风险相关。⁴由于缺乏合适的诊断性生物标志物和有效的治疗方法，患者往往被诊断为晚期，死亡率不断上升。⁵考虑到这些问题，有必要在基因水平上研究 TCC 以表征靶向药物。