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Neuro-Immune Cell Units: A New Paradigm in Physiology.
Annual Review of Immunology ( IF 29.7 ) Pub Date : 2018-10-31 , DOI: 10.1146/annurev-immunol-042718-041812
Cristina Godinho-Silva 1 , Filipa Cardoso 1 , Henrique Veiga-Fernandes 1
Affiliation  

The interplay between the immune and nervous systems has been acknowledged in the past, but only more recent studies have started to unravel the cellular and molecular players of such interactions. Mounting evidence indicates that environmental signals are sensed by discrete neuro-immune cell units (NICUs), which represent defined anatomical locations in which immune and neuronal cells colocalize and functionally interact to steer tissue physiology and protection. These units have now been described in multiple tissues throughout the body, including lymphoid organs, adipose tissue, and mucosal barriers. As such, NICUs are emerging as important orchestrators of multiple physiological processes, including hematopoiesis, organogenesis, inflammation, tissue repair, and thermogenesis. In this review we focus on the impact of NICUs in tissue physiology and how this fast-evolving field is driving a paradigm shift in our understanding of immunoregulation and organismal physiology.

中文翻译:

神经免疫细胞单位:生理学的新范式。

免疫系统和神经系统之间的相互作用在过去已经得到公认,但是只有最近的研究才开始揭示这种相互作用的细胞和分子参与者。越来越多的证据表明,环境信号是由离散的神经免疫细胞单元(NICU)感测到的,这些单元代表免疫和神经元细胞共定位并在功能上相互作用以引导组织生理和保护的明确解剖位置。现在已经在全身的多个组织中描述了这些单位,包括淋巴器官,脂肪组织和粘膜屏障。这样,NICU逐渐成为多种生理过程(包括造血,器官发生,炎症,组织修复和生热)的重要协调者。
更新日期:2020-04-21
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