The B cell antigen receptor (BCR) plays a central role in the self/nonself selection of B lymphocytes and in their activation by cognate antigen during the clonal selection process. It was long thought that most cell surface receptors, including the BCR, were freely diffusing and randomly distributed. Since the advent of superresolution techniques, it has become clear that the plasma membrane is compartmentalized and highly organized at the nanometer scale. Hence, a complete understanding of the precise conformation and activation mechanism of the BCR must take into account the organization of the B cell plasma membrane. We review here the recent literature on the nanoscale organization of the lymphocyte membrane and discuss how this new information influences our view of the conformational changes that the BCR undergoes during activation.

中文翻译：

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B细胞膜的纳米级组织中的抗原受体功能。

在克隆选择过程中，B细胞抗原受体（BCR）在B淋巴细胞的自身/非自身选择以及它们通过同源抗原的激活中起着核心作用。长期以来，大多数细胞表面受体，包括BCR，都可以自由扩散并随机分布。自从超分辨率技术问世以来，已经清楚的是，质膜在纳米尺度上是分隔开的并且高度组织化。因此，对BCR的精确构象和激活机制的完整理解必须考虑到B细胞质膜的组织。我们在这里回顾有关淋巴细胞膜的纳米级组织的最新文献，并讨论该新信息如何影响我们对BCR在激活过程中经历的构象变化的看法。