Adaptive immune recognition is mediated by antigen receptors on B and T cells generated by somatic recombination during lineage development. The high level of diversity resulting from this process posed technical limitations that previously limited the comprehensive analysis of adaptive immune recognition. Advances over the last ten years have produced data and approaches allowing insights into how T cells develop, evolutionary signatures of recombination and selection, and the features of T cell receptors that mediate epitope-specific binding and T cell activation. The size and complexity of these data have necessitated the generation of novel computational and analytical approaches, which are transforming how T cell immunology is conducted. Here we review the development and application of novel biological, theoretical, and computational methods for understanding T cell recognition and discuss the potential for improved models of receptor:antigen interactions.

中文翻译：

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使用T细胞受体库了解自适应免疫识别的原理。

适应性免疫识别由谱系发育过程中体细胞重组产生的B细胞和T细胞上的抗原受体介导。此过程导致的高度多样性带来了技术限制，这些限制以前限制了对自适应免疫识别的全面分析。过去十年的发展产生了数据和方法，使人们能够洞悉T细胞的发育，重组和选择的进化特征以及介导表位特异性结合和T细胞活化的T细胞受体的特征。这些数据的大小和复杂性使得必须产生新颖的计算和分析方法，这正在改变T细胞免疫学的进行方式。在这里，我们回顾了新型生物学，理论，