Spatiotemporal changes in the abundance, shape, and cellular localization of the mitochondrial network, also known as mitochondrial dynamics, are now widely recognized to play a key role in mitochondrial and cellular physiology as well as disease states. This process involves coordinated remodeling of the outer and inner mitochondrial membranes by conserved dynamin-like guanosine triphosphatases and their partner molecules in response to various physiological and stress stimuli. Although the core machineries that mediate fusion and partitioning of the mitochondrial network have been extensively characterized, many aspects of their function and regulation are incompletely understood and only beginning to emerge. In the present review we briefly summarize current knowledge about how the key mitochondrial dynamics-mediating factors are regulated via selective proteolysis by mitochondrial and cellular proteolytic machineries.

中文翻译：

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线粒体动力学的蛋白水解调节

线粒体网络的丰度、形状和细胞定位的时空变化，也称为线粒体动力学，现在被广泛认为在线粒体和细胞生理学以及疾病状态中起着关键作用。该过程涉及通过保守的动力蛋白样鸟苷三磷酸酶及其伙伴分子响应各种生理和压力刺激对线粒体外膜和内膜进行协调重塑。尽管介导线粒体网络融合和分割的核心机制已被广泛表征，但其功能和调节的许多方面尚未完全了解，才刚刚开始出现。