We aimed to assess the correlation between premature ejaculation (PE), lower urinary tract symptoms (LUTS), erectile dysfunction (ED), and depression in the cohort of the last 329 patients seeking medical help for distressing early ejaculation at a single tertiary-referral center. All patients completed the premature ejaculation diagnostic tool (PEDT), the International Index of Erectile Function (IIEF), the Beck’s Inventory for Depression (BDI), and the International Prostate Symptom Score (IPSS) at their first assessment. Overall, 133 (0.4) patients had PEDT ≥ 11, suggestive for PE. The characteristics of patients with and without PE according to PEDT findings were compared with the Mann–Whitney and Fisher’s exact tests. Linear regression analysis tested the association between LUTS and PEDT score. Patients with PE depicted lower median scores for IIEF-overall satisfaction, intercourse satisfaction and erectile function than non-PE individuals (all p < 0.004). Similarly, patients with PE showed higher median BDI scores (7 versus 4; p < 0.0002), median IPSS total score (7 versus 5), storage (4 versus 2), and voiding (3 versus 2) subscores (all p < 0.01) compared to those without PE. At linear regression analysis, IPSS storage subscore (Coeff: 0.28; 95%CI: 0.05–0.51, p = 0.01) and BDI score (Coeff: 0.10; 95%CI: 0.01–0.19, p = 0.02) were associated with higher PEDT values, after accounting for IIEF-EF score, patients’ age, body mass index and Charlson Comorbidity Index. Our findings suggest that storage symptoms and depression should be carefully investigated when assessing patients complaining of PE in the real-life setting.

我们的目的是评估最后329名因单次三级转诊而困扰早期射精的患者寻求医疗帮助的队列中，早泄（PE），下尿路症状（LUTS），勃起功能障碍（ED）和抑郁症之间的相关性中央。所有患者在首次评估时均完成了早泄诊断工具（PEDT），国际勃起功能指数（IIEF），贝克抑郁量表（BDI）和国际前列腺症状评分（IPSS）。总体上，有133（0.4）名患者的PEDT≥11，提示存在PE。根据PEDT的发现将有无PE患者的特征与Mann-Whitney和Fisher的精确检验进行了比较。线性回归分析检验了LUTS和PEDT评分之间的关​​联。p  <0.004）。同样，PE患者表现出较高的BDI中位数（7对4；p  <0.0002），IPSS总中位数（7对5），存储（4对2）和排尿（3对2）子评分（所有p  <0.01） ）与没有PE的人群相比。在线性回归分析中，IPSS存储分值（Coeff：0.28； 95％CI：0.05–0.51，p  = 0.01）和BDI评分（Coeff：0.10； 95％CI：0.01–0.19，p  = 0.02）与更高的PEDT相关在计算IIEF-EF分数，患者年龄，体重指数和Charlson合并症指数后得出的值。我们的发现表明，在评估真实环境中抱怨PE的患者时，应仔细研究存储症状和抑郁症。