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Function and Compensatory Mechanisms Among the Components of the Chloroplastic Redox Network
Critical Reviews in Plant Sciences ( IF 6.9 ) Pub Date : 2018-11-05 , DOI: 10.1080/07352689.2018.1528409
Paulo V. L. Souza 1 , Yugo Lima-Melo 1, 2 , Fabricio E. Carvalho 1 , Jean-Philippe Reichheld 3 , Alisdair R. Fernie 4 , Joaquim A. G. Silveira 1 , Danilo M. Daloso 1
Affiliation  

Abstract Life on earth depends on the presence of photoautotrophic organisms that are able to input carbon into the ecosystems through the process of photosynthesis which, with a few specialized exceptions, takes place within the chloroplast. This organelle contains the most complex redox system in plants being composed of numerous players including thiol reductases, peroxidases, and glutathione-related enzymes. It seems likely that these proteins act together to adjust redox metabolism enabling plants to grow efficiently under both normal and stressed conditions. However, our knowledge concerning how these proteins interact and if they can compensate one another is relatively limited. This is in part due to the failure of considering these components from a systemic perspective. Here, we provide a systemic view of the chloroplastic-redox network highlighting how it operates and how its components co-operate to maintain efficient chloroplastic function. We further explore the cross-talk between chloroplastic-redox metabolism and that of other subcellular compartments. Given the complexity of plant redox metabolism and the compensatory role played by different redox systems, we argue that a unique possibility to understand this system is afforded by systems biology approaches and by characterizing mutants for multiple genes. Taking this into account, we highlight how gene co-expression and protein–protein network analyses coupled with different reverse genetic strategies could be used to reveal the function, potential redundancies, and complementarities among the components of the chloroplastic redox network.

中文翻译:

氯塑料氧化还原网络各组成部分的功能和补偿机制

摘要 地球上的生命依赖于光合自养生物的存在,这些生物能够通过光合作用过程将碳输入生态系统,除了少数特殊的例外,光合作用发生在叶绿体中。该细胞器包含植物中最复杂的氧化还原系统,由众多参与者组成,包括硫醇还原酶、过氧化物酶和谷胱甘肽相关酶。似乎这些蛋白质共同作用以调节氧化还原代谢,使植物在正常和压力条件下都能有效生长。然而,我们关于这些蛋白质如何相互作用以及它们是否可以相互补偿的知识相对有限。这部分是由于未能从系统的角度考虑这些组成部分。这里,我们提供了叶绿体-氧化还原网络的系统视图,重点介绍了它的运作方式以及其组件如何协同工作以维持有效的叶绿体功能。我们进一步探索叶绿体-氧化还原代谢与其他亚细胞区室之间的串扰。鉴于植物氧化还原代谢的复杂性和不同氧化还原系统所起的补偿作用,我们认为系统生物学方法和通过表征多个基因的突变体为理解该系统提供了独特的可能性。考虑到这一点,我们强调了如何使用基因共表达和蛋白质-蛋白质网络分析以及不同的反向遗传策略来揭示叶绿体氧化还原网络组件之间的功能、潜在的冗余和互补性。
更新日期:2018-11-05
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