The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory responses that promote the rapid clearance of pathogens but also contribute to pathology in chronic inflammation. Therapeutic interventions manipulating these cytokines are approved for use in some cancers as well as allergic and autoimmune disease, and others show promising early clinical activity. These approaches are based on our understanding of the inflammatory roles of these cytokines; however, GM-CSF also participates in the resolution of inflammation, and IL-3 and IL-5 may also have such properties. Here, we review the functions of the β common cytokines in health and disease. We discuss preclinical and clinical data, highlighting the potential inherent in targeting these cytokine pathways, the limitations, and the important gaps in understanding of the basic biology of this cytokine family.

β共有链细胞因子GM-CSF，IL-3和IL-5调节各种炎症反应，从而促进病原体的快速清除，但也有助于慢性炎症的病理学。批准了操纵这些细胞因子的治疗性干预措施，可用于某些癌症以及变态反应和自身免疫性疾病，而另一些则显示出令人鼓舞的早期临床活性。这些方法是基于我们对这些细胞因子的炎性作用的理解。但是，GM-CSF也参与炎症的消退，而IL-3和IL-5也可能具有这种特性。在这里，我们回顾了β常见细胞因子在健康和疾病中的功能。我们讨论了临床前和临床数据，重点介绍了靶向这些细胞因子途径的内在潜力，局限性，