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Immune Signaling in Neurodegeneration.
Immunity ( IF 32.4 ) Pub Date : 2019-04-16 , DOI: 10.1016/j.immuni.2019.03.016
Timothy R Hammond 1 , Samuel E Marsh 1 , Beth Stevens 2
Affiliation  

Neurodegenerative diseases of the central nervous system progressively rob patients of their memory, motor function, and ability to perform daily tasks. Advances in genetics and animal models are beginning to unearth an unexpected role of the immune system in disease onset and pathogenesis; however, the role of cytokines, growth factors, and other immune signaling pathways in disease pathogenesis is still being examined. Here we review recent genetic risk and genome-wide association studies and emerging mechanisms for three key immune pathways implicated in disease, the growth factor TGF-β, the complement cascade, and the extracellular receptor TREM2. These immune signaling pathways are important under both healthy and neurodegenerative conditions, and recent work has highlighted new functional aspects of their signaling. Finally, we assess future directions for immune-related research in neurodegeneration and potential avenues for immune-related therapies.

中文翻译:

神经退行性疾病中的免疫信号传导。

中枢神经系统的神经退行性疾病逐渐剥夺患者的记忆力、运动功能和执行日常任务的能力。遗传学和动物模型的进步开始揭示免疫系统在疾病发生和发病机制中的意想不到的作用;然而,细胞因子、生长因子和其他免疫信号通路在疾病发病机制中的作用仍在研究中。在这里,我们回顾了最近的遗传风险和全基因组关联研究以及与疾病有关的三个关键免疫途径(生长因子 TGF-β、补体级联和细胞外受体 TREM2)的新兴机制。这些免疫信号通路在健康和神经退行性条件下都很重要,最近的工作强调了其信号传导的新功能方面。最后,我们评估了神经退行性疾病免疫相关研究的未来方向以及免疫相关治疗的潜在途径。
更新日期:2019-04-16
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