Blueberries are rich in polyphenols that may be beneficial to cognitive performance and mood. The aim of this systematic review was to evaluate randomized controlled trials investigating the effects of blueberries and blueberry products on measures of cognition and mood. In total, eleven articles (that included 12 studies) were identified using freeze-dried blueberries (n = 9 studies), whole blueberries (n = 2) and blueberry concentrate (n = 1). These studies were conducted in children (n = 5), young adults (n = 1), and older people with either no known cognitive impairment (n = 4) or indicated cognitive impairment (n = 2). Eight studies reported blueberry consumption or supplementation at various doses and time lengths to improve measures of cognitive performance, particularly short- and long-term memory and spatial memory. For mood, one study reported significant between-group improvements in positive affect from blueberry products, whereas four studies reported no improvement. Low risk of bias were observed across all studies. Based on the current evidence, blueberries may improve some measures of cognitive performance. However, considerable differences in study design, dosages, and anthocyanin content hinder between-study comparison. The use of standardized blueberry interventions, consideration of placebo formulations, and consistently reported cognitive performance tools are recommended in future trials. PROSPERO registration no. CRD42018100888.

中文翻译：

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蓝莓干预对认知表现和情绪的影响：随机对照试验的系统评价

蓝莓富含多酚，可能有益于认知能力和情绪。本系统评价的目的是评估随机对照试验，研究蓝莓和蓝莓产品对认知和情绪测量的影响。总共有 11 篇文章（包括 12 项研究）使用冻干蓝莓（n = 9 项研究）、整个蓝莓（n = 2）和蓝莓浓缩物（n = 1）进行鉴定。这些研究是在没有已知认知障碍 (n = 4) 或有认知障碍 (n = 2) 的儿童 (n = 5)、年轻人 (n = 1) 和老年人中进行的。八项研究报告了不同剂量和时间长度的蓝莓消费或补充剂，以改善认知表现，特别是短期和长期记忆和空间记忆。为了心情，一项研究报告了蓝莓产品的积极影响在组间显着改善，而四项研究报告没有改善。在所有研究中均观察到低偏倚风险。根据目前的证据，蓝莓可能会改善认知表现的一些指标。然而，研究设计、剂量和花青素含量的巨大差异阻碍了研究之间的比较。建议在未来的试验中使用标准化的蓝莓干预措施、考虑安慰剂配方和一致报告的认知表现工具。PROSPERO 注册号 CRD42018100888。蓝莓可能会改善认知表现的一些措施。然而，研究设计、剂量和花青素含量的巨大差异阻碍了研究之间的比较。建议在未来的试验中使用标准化的蓝莓干预措施、考虑安慰剂制剂和一致报告的认知表现工具。PROSPERO 注册号 CRD42018100888。蓝莓可能会改善认知表现的一些措施。然而，研究设计、剂量和花青素含量的巨大差异阻碍了研究之间的比较。建议在未来的试验中使用标准化的蓝莓干预措施、考虑安慰剂配方和一致报告的认知表现工具。PROSPERO 注册号 CRD42018100888。