Acute wound healing is an orderly process of four overlapping events: haemostasis, inflammation, proliferation and remodelling. A drug delivery system with a temporal control of release could promote each of these events sequentially. However, acute wound healing normally proceeds very well in healthy individuals and there is little need to promote it. In the elderly and diabetics however, healing is often slow and wounds can become chronic and we need to promote their healing. Targeting the events of acute wound healing would not be appropriate for a chronic wound, which have stalled in the proinflammatory phase. They also have many additional problems such as poor circulation, low oxygen, high levels of leukocytes, high reactive oxygen species, high levels of proteolytic enzymes, high levels of proinflammatory cytokines, bacterial infection and high pH. The future challenge will be to tackle each of these negative factors to create a wound environment conducive to healing.

急性伤口愈合是四个重叠事件的有序过程：止血，炎症，增殖和重塑。具有释放的时间控制的药物递送系统可以依次促进这些事件中的每一个。但是，急性伤口愈合通常在健康个体中进行得很好，几乎没有必要进行促进。但是，在老年人和糖尿病患者中，愈合通常很慢，伤口可能会变成慢性伤口，我们需要促进其愈合。针对急性伤口愈合的事件，不适用于已陷入促炎期的慢性伤口。它们还存在许多其他问题，例如血液循环不良，低氧，白细胞水平高，活性氧含量高，蛋白水解酶水平高，促炎细胞因子水平高，细菌感染和高pH值。未来的挑战将是解决所有这些负面因素，以创造一个有利于愈合的伤口环境。