Phase‐I metabolism mediated by cytochrome P450 (CYP) enzymes represents a major route of elimination of many drugs that can compete for the same CYP enzyme. The bioactivity of essential oils (EOs) and their flavour and fragrance constituents have been known since ancient times, and like any other physiological process in the human body the activity of CYP enzymes can also be influenced (increased and/or decreased) by these natural compounds. This review discusses the effects of EO constituents on important drug‐metabolizing CYP enzymes. Exposure to EO constituents through commonly used products via cutaneous, oral, and inhalation routes is outlined, and the impact of some important EO constituents on CYP enzymes is described in more detail. In particular, the simultaneous application of EO constituents with drugs or the excessive use of EOs and their constituents can lead to unexpected adverse effects.

中文翻译：

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精油成分和细胞色素P450酶的综述

由细胞色素P450（CYP）酶介导的I期代谢是消除许多可竞争同一CYP酶的药物的主要途径。精油（EOs）的生物活性及其风味和香气成分自古以来就已广为人知，并且与人体中的任何其他生理过程一样，CYP酶的活性也可能受到这些天然油的影响（增加和/或减少）。化合物。这篇综述讨论了EO成分对重要的药物代谢CYP酶的影响。概述了通过皮肤，口服和吸入途径通过常用产品对EO成分的暴露，并详细描述了一些重要的EO成分对CYP酶的影响。特别是，