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Ceramide synthases in cancer therapy and chemoresistance
Progress in Lipid Research ( IF 13.6 ) Pub Date : 2019-04-04 , DOI: 10.1016/j.plipres.2019.04.002
Sebastian Brachtendorf , Khadija El-Hindi , Sabine Grösch

Drug resistance is one major reason for failure of cancer therapy. In the past 10 years, evidence emerged showing that ceramides of specific chain length, generated by six different ceramide synthases (CerS), are deregulated in different cancer types thereby influencing chemosensitivity. In this review we sum up the cellular mechanisms regulated by CerS and the respective ceramides of specific chain length contributing to chemoresistance and how we can interfere with these mechanisms to overcome drug resistance by targeting CerS. We compile an overview of the different cellular effects influenced by CerS in dependency of the used drug and cancer type. Finally, the potential of CerS as new drug targets in chemotherapy or as biomarkers for the prediction of therapeutic response rates is discussed.



中文翻译:

神经酰胺合酶在癌症治疗和化学抗性中的作用

耐药性是癌症治疗失败的主要原因之一。在过去的十年中,有证据表明,由六种不同的神经酰胺合酶(CerS)生成的特定链长的神经酰胺在不同类型的癌症中被解除调节,从而影响化学敏感性。在这篇综述中,我们总结了由CerS调控的细胞机制以及特定链长的各自的神经酰胺,它们有助于化学抗性,以及我们如何通过靶向CerS来干扰这些机制以克服耐药性。我们对所用药物和癌症类型的依赖关系汇总了受CerS影响的不同细胞效应的概述。最后,讨论了CerS作为化学疗法中新药靶标或预测治疗反应率的生物标志物的潜力。

更新日期:2019-04-04
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