There is limited information on how indoor tanning promotes melanoma development. We investigated indoor tanning use in patients with melanomas in sun-exposed skin and studied the clinicopathological and molecular characteristics in relation to indoor tanning exposure. Patients from a multidisciplinary clinic for cutaneous cancers completed standardized questionnaires on risk factors for melanoma as a component of medical history at their initial consultations. For this study, we included patients from December 2013 to May 2015. The 114 patients who reported indoor tanning exposure were younger at diagnosis than the 222 patients who did not (51.5 vs 64.0 years, two-sided P < .001). BRAF V600E genotype was more prevalent in ever-users than in nonusers (42.9% vs 28.3%, two-sided P = .04) and higher in ever-users who initiated indoor tanning prior to age 25 years compared with age 25 years or older (62.2% vs 31.1%, two-sided P = .003). There were more melanomas in intermittently sun-exposed skin in ever-users than nonusers (65.7% vs 51.9%, respectively, two-sided P = .02). Our data suggest indoor tanning may promote melanomas that arise in skin with low-chronic sun-induced damage through BRAF V600E-mediated melanomagenesis.

中文翻译：

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室内晒黑暴露与黑色素瘤诊断年龄和BRAF V600E突变的关联。

关于室内晒黑如何促进黑色素瘤发展的信息有限。我们调查了晒黑皮肤黑素瘤患者的室内日光浴使用情况，并研究了与室内日光浴暴露有关的临床病理和分子特征。来自皮肤癌多学科诊所的患者在初诊时就填写了关于黑色素瘤危险因素的标准化问卷，这是病史的一部分。在本研究中，我们纳入了2013年12月至2015年5月的患者。114例报告室内晒黑暴露的患者比222例未进行室内晒黑的患者诊断年轻（51.5 vs 64.0岁，两侧P <.001）。BRAF V600E基因型在经常使用的人群中比在未使用的人群中更为普遍（42.9％vs 28.3％，双向P =。04）以及25岁之前开始室内晒黑的用户中高于25岁或25岁以上的用户（62.2％vs 31.1％，双面P = 0.003）。经常使用的人中，间歇性暴露在阳光下的皮肤中的黑色素瘤比不使用者的多（分别为65.7％和51.9％，两侧P = .02）。我们的数据表明，室内晒黑可能通过BRAF V600E介导的黑色素瘤生成促进皮肤黑素瘤的产生，这种皮肤黑素是由低时光引起的。