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Maturational Changes in Human Dorsal and Ventral Visual Networks.
Cerebral Cortex ( IF 3.7 ) Pub Date : 2019-12-17 , DOI: 10.1093/cercor/bhz053
Kristina T R Ciesielski 1, 2 , Moriah E Stern 2 , Adele Diamond 3 , Sheraz Khan 1, 4 , Evelina A Busa 1 , Timothy E Goldsmith 2 , Andre van der Kouwe 1 , Bruce Fischl 1, 4 , Bruce R Rosen 1, 4
Affiliation  

Developmental neuroimaging studies report the emergence of increasingly diverse cognitive functions as closely entangled with a rise-fall modulation of cortical thickness (CTh), structural cortical and white-matter connectivity, and a time-course for the experience-dependent selective elimination of the overproduced synapses. We examine which of two visual processing networks, the dorsal (DVN; prefrontal, parietal nodes) or ventral (VVN; frontal-temporal, fusiform nodes) matures first, thus leading the neuro-cognitive developmental trajectory. Three age-dependent measures are reported: (i) the CTh at network nodes; (ii) the matrix of intra-network structural connectivity (edges); and (iii) the proficiency in network-related neuropsychological tests. Typically developing children (age ~6 years), adolescents (~11 years), and adults (~21 years) were tested using multiple-acquisition structural T1-weighted magnetic resonance imaging (MRI) and neuropsychology. MRI images reconstructed into a gray/white/pial matter boundary model were used for CTh evaluation. No significant group differences in CTh and in the matrix of edges were found for DVN (except for the left prefrontal), but a significantly thicker cortex in children for VVN with reduced prefrontal ventral-fusiform connectivity and with an abundance of connections in adolescents. The higher performance in children on tests related to DVN corroborates the age-dependent MRI structural connectivity findings. The current findings are consistent with an earlier maturational course of DVN.

中文翻译:

人类背侧和腹侧视觉网络的成熟变化。

发展性神经影像学研究报道了越来越多的认知功能的出现,这些功能与皮层厚度(CTh)的上升-下降调制,结构性皮层和白色物质的连通性以及依赖于经验的选择性消除过度生产的时间过程紧密相关突触。我们研究了两个视觉处理网络中的哪个(背侧(DVN;前额叶,顶叶淋巴结)或腹侧(VVN;额颞叶,梭状结节))最先成熟,从而引导了神经认知发展轨迹。报告了三种与年龄有关的措施:(i)网络节点处的CTh;(ii)网络内结构连接性矩阵(边缘);(iii)熟练掌握网络相关的神经心理学测试。通常是发育中的儿童(约6岁),青少年(约11岁),成年人和成人(〜21岁)使用多重获取的T1加权磁共振成像(MRI)和神经心理学进行了测试。将重建为灰色/白色/黑物质边界模型的MRI图像用于CTh评估。对于DVN(左前额叶除外),在CTh和边缘矩阵中没有发现显着的群体差异,但是对于VVN,儿童的皮质明显厚得多,前额叶腹膜梭形连接性降低,并且青少年中连接丰富。儿童在与DVN相关的测试中表现更高,证实了年龄相关的MRI结构连接性发现。目前的发现与DVN的成熟过程相一致。将重建为灰色/白色/黑物质边界模型的MRI图像用于CTh评估。对于DVN(左前额叶除外),在CTh和边缘矩阵中没有发现显着的群体差异,但是对于VVN,儿童的皮质明显厚得多,前额叶腹膜梭形连接性降低,并且青少年中连接丰富。儿童在与DVN相关的测试中表现更高,证实了年龄相关的MRI结构连接性发现。目前的发现与DVN的成熟过程相一致。重建为灰色/白色/黑物质边界模型的MRI图像用于CTh评估。对于DVN(左前额叶除外),在CTh和边缘矩阵中没有发现显着的群体差异,但是对于VVN,儿童的皮质明显厚得多,前额叶腹膜梭形连接性降低,并且青少年中连接丰富。儿童在与DVN相关的测试中表现更高,证实了年龄相关的MRI结构连接性发现。目前的发现与DVN的成熟过程相一致。但对于VVN,儿童的皮质明显增厚,前额腹-梭状连接减少,且青少年连接丰富。儿童在与DVN相关的测试中表现更高,证实了年龄相关的MRI结构连接性发现。目前的发现与DVN的成熟过程相一致。但对于VVN,儿童的皮质明显增厚,前额腹-梭状连接减少,且青少年连接丰富。儿童在与DVN相关的测试中表现更高,证实了年龄相关的MRI结构连接性发现。目前的发现与DVN的成熟过程相一致。
更新日期:2019-12-19
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