The development of techniques to create and use multiphase microstructured hydrogels (granular hydrogels or microgels) has enabled the generation of cultures with more biologically relevant architecture and use of structured hydrogels is especially pertinent to the development of new types of central nervous system (CNS) culture models and therapies. We review material choice and the customisation of hydrogel structure, as well as the use of hydrogels in developmental models. Combining the use of structured hydrogel techniques with developmentally relevant tissue culture approaches will enable the generation of more relevant models and treatments to repair damaged CNS tissue architecture.

建立和使用多相微结构水凝胶（粒状水凝胶或微凝胶）的技术的发展使具有生物相关结构的培养物的产生成为可能，结构化水凝胶的使用尤其与新型中枢神经系统（CNS）培养物的开发有关模型和疗法。我们审查材料的选择和水凝胶结构的定制，以及在发展模型中水凝胶的使用。将结构化水凝胶技术与发展相关的组织培养方法结合使用，将能够生成更相关的模型和治疗方法，以修复受损的CNS组织结构。