Background

Musculoskeletal disorders are a group of disorders that affect the joints, bones, and muscles, causing long-term disability. Berberine, an isoquinoline alkaloid, has been previously established to exhibit beneficial properties in preventing various diseases, including musculoskeletal disorders.

Purpose

This review article aims to recapitulate the therapeutic potential of berberine and its mechanism of action in treating musculoskeletal disorders.

Methods

A wide range of literature illustrating the effects of berberine in ameliorating musculoskeletal disorders was retrieved from online electronic databases (PubMed and Medline) and reviewed.

Results

Berberine may potentially retard the progression of osteoporosis, osteoarthritis and rheumatoid arthritis. Limited studies reported the effects of berberine in suppressing the proliferation of osteosarcoma cells. These beneficial properties of berberine are mediated in part through its ability to target multiple signaling pathways, including PKA, p38 MAPK, Wnt/β-catenin, AMPK, RANK/RANKL/OPG, PI3K/Akt, NFAT, NF-κB, Hedgehog, and oxidative stress signaling. In addition, berberine exhibited anti-apoptotic, anti-inflammatory, and immunosuppressive properties.

Conclusion

The current evidence indicates that berberine may be effective in preventing musculoskeletal disorders. However, findings from in vitro and in vivo investigations await further validation from human clinical trial.

中文翻译：

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小ber碱和肌肉骨骼疾病：治疗潜力和潜在的分子机制。

背景

肌肉骨骼疾病是一组影响关节，骨骼和肌肉，导致长期残疾的疾病。小ber碱，一种异喹啉生物碱，先前已被证实具有预防各种疾病（包括肌肉骨骼疾病）的有益特性。

目的

这篇综述文章旨在概述小ber碱的治疗潜力及其在治疗肌肉骨骼疾病中的作用机理。

方法

从在线电子数据库（PubMed和Medline）中检索并综述了许多文献，这些文献说明了小ber碱在改善肌肉骨骼疾病中的作用。

结果

小ber碱可能会延迟骨质疏松症，骨关节炎和类风湿关节炎的进展。有限的研究报道了小ber碱在抑制骨肉瘤细胞增殖中的作用。小ber碱的这些有益特性部分是通过其靶向多种信号通路的能力介导的，这些通路包括PKA，p38 MAPK，Wnt /β-catenin，AMPK，RANK / RANKL / OPG，PI3K / Akt，NFAT，NF-κB，Hedgehog，和氧化应激信号。此外，小ber碱还具有抗凋亡，抗炎和免疫抑制的特性。

结论

目前的证据表明，小ber碱可能有效预防肌肉骨骼疾病。但是，来自体外和体内研究的结果尚待人类临床试验进一步证实。