Since the initial suggestion that rapamycin, an inhibitor of target of rapamycin (TOR) nutrient signaling, increased lifespan comparable to dietary restriction, investigators have viewed rapamycin as a potential dietary restriction mimetic. Both dietary restriction and rapamycin increase lifespan across a wide range of evolutionarily diverse species (including yeast, Caenorhabditis elegans, Drosophila, and mice) as well as reducing pathology and improving physiological functions that decline with age in mice. The purpose of this article is to review the research comparing the effect of dietary restriction and rapamycin in mice. The current data show that dietary restriction and rapamycin have different effects on many pathways and molecular processes. In addition, these interventions affect the lifespan of many genetically manipulated mouse models differently. In other words, while dietary restriction and rapamycin may have similar effects on some pathways and processes; overall, they affect many pathways/processes quite differently. Therefore, rapamycin is likely not a true dietary restriction mimetic. Rather dietary restriction and rapamycin appear to be increasing lifespan and retarding aging largely through different mechanisms/pathways, suggesting that a combination of dietary restriction and rapamycin will have a greater effect on lifespan than either manipulation alone.

中文翻译：

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雷帕霉素是一种饮食限制模拟物吗？

自最初提出雷帕霉素（雷帕霉素靶点 (TOR) 营养信号转导抑制剂）与饮食限制相比可延长寿命以来，研究人员已将雷帕霉素视为潜在的饮食限制模拟物。饮食限制和雷帕霉素可延长多种进化多样性物种（包括酵母、秀丽隐杆线虫、果蝇和小鼠）的寿命，并减少小鼠的病理并改善随年龄增长而下降的生理功能。本文的目的是回顾比较饮食限制和雷帕霉素对小鼠的影响的研究。目前的数据表明，饮食限制和雷帕霉素对许多通路和分子过程有不同的影响。此外，这些干预措施以不同方式影响许多基因操作小鼠模型的寿命。换句话说，虽然饮食限制和雷帕霉素可能对某些途径和过程具有相似的作用；总的来说，它们对许多途径/过程的影响截然不同。因此，雷帕霉素可能不是真正的饮食限制模拟物。相反，饮食限制和雷帕霉素似乎主要通过不同的机制/途径延长寿命和延缓衰老，这表明饮食限制和雷帕霉素的组合对寿命的影响比单独使用任何一种都大。雷帕霉素可能不是真正的饮食限制模拟物。相反，饮食限制和雷帕霉素似乎主要通过不同的机制/途径延长寿命和延缓衰老，这表明饮食限制和雷帕霉素的组合对寿命的影响比单独使用任何一种都大。雷帕霉素可能不是真正的饮食限制模拟物。相反，饮食限制和雷帕霉素似乎主要通过不同的机制/途径延长寿命和延缓衰老，这表明饮食限制和雷帕霉素的组合对寿命的影响比单独使用任何一种都大。