OBJECTIVE Women exposed to childhood maltreatment (CM) are more likely to exhibit insensitive parenting, which may have consequences for their offspring's development. Variation in the oxytocin-receptor gene (OXTR) moderates risk of CM-associated long-term sequelae associated with mother-child attachment, although functionality of previously investigated single nucleotide polymorphisms (SNPs) remained elusive. Here, we investigated the role of OXTR rs237895, a brain tissue expression quantitative trait locus (eQTL), as a moderator of the relationship between CM and maternal behavior (MB) and the association between MB and offspring attachment security. METHOD Of 110 women with information on rs237895 genotype (T-allele = 64, CC = 46), 107 had information on CM (CTQ) and 99 on standardized observer-based ratings of MB at 6 months postpartum (responsivity and detachment), which were used in principal component analysis to obtain a latent factor representing MB. Offspring (n = 86) attachment was evaluated at 12 months of age. Analyses predicting MB were adjusted for socioeconomic status, age, postpartum depression, and genotype-based ethnicity. Analyses predicting child attachment were adjusted for infant sex, socioeconomic status, and postpartum depression. RESULTS rs237895 significantly moderated the relationship between CM and MB (F1;66 = 7.99, p < .01), indicating that CM was associated with maternal insensitivity only in high-OXTR-expressing T-allele carriers but not in low-OXTR-expressing CC homozygotes. Moreover, maternal insensitivity predicted offspring insecure attachment (B = -0.551; p < .05). CONCLUSION Women with a high OXTR expressing genotype are more susceptible to CM-related impairments in MB that, in turn, predict attachment security in their children, supporting the role of the OT system in the intergenerational transmission of risk associated with maternal CM.

中文翻译：

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催产素受体基因脑组织表达数量性状位点rs237895在母亲童年虐待影响代际传递中的作用。

目标 遭受童年虐待 (CM) 的女性更有可能表现出不敏感的养育方式，这可能对其后代的发育产生影响。尽管先前研究的单核苷酸多态性 (SNP) 的功能仍然难以捉摸，但催产素受体基因 (OXTR) 的变异可降低与母子依恋相关的 CM 相关长期后遗症的风险。在这里，我们研究了脑组织表达数量性状基因座 (eQTL) OXTR rs237895 作为 CM 和母性行为 (MB) 之间关系以及 MB 和后代依恋安全性之间关联的调节因子的作用。方法 在 110 名拥有 rs237895 基因型信息（T 等位基因 = 64，CC = 46）的女性中，107 名女性拥有 CM (CTQ) 信息，99 名女性拥有产后 6 个月时基于观察者的标准化 MB 评级（反应性和脱离性），其中用于主成分分析以获得代表MB的潜在因子。后代 (n = 86) 在 12 个月大时进行依恋评估。预测 MB 的分析根据社会经济地位、年龄、产后抑郁症和基于基因型的种族进行了调整。预测儿童依恋的分析根据婴儿性别、社会经济地位和产后抑郁症进行了调整。结果 rs237895 显着调节 CM 和 MB 之间的关系 (F1;66 = 7.99, p < .01)，表明 CM 仅在高 OXTR 表达的 T 等位基因携带者中与母体不敏感相关，而在低 OXTR 表达的携带者中则不然。 CC 纯合子。此外，母亲的不敏感预示着后代不安全的依恋（B = -0.551；p < .05）。结论 具有高 OXTR 表达基因型的女性更容易受到 CM 相关的 MB 损伤，这反过来又可以预测其子女的依恋安全性，支持 OT 系统在与母亲 CM 相关的风险代际传播中的作用。